慢性鼻-鼻窦炎合并呼吸道合胞病毒感染危险因素及IL-7、IL-33表达  

Risk factors for respiratory syncytial virus infection and expressions of IL-7,IL-33 in patients with chronic rhino-sinusitis

作　　者：谢鼎骏 周详 刘艳锋[1] 姜顺明[1] 汪红明 XIE Ding-jun;ZHOU Xiang;LIU Yan-feng;JIANG Shun-ming;WANG Hong-ming(Jiande Branch of The Second Affiliated Hospital of Zhejiang Medical University(Jiande First People's Hospital),Jiande,Zhejiang 3l1600,China)

机构地区：[1]浙江医科大学附属第二医院建德分院(建德市第一人民医院)耳鼻咽喉科,浙江建德311600

出　　处：《中华医院感染学杂志》2023年第9期1371-1374,共4页Chinese Journal of Nosocomiology

基　　金：浙江省科研基金资助项目(2018C37058)。

摘　　要：目的分析慢性鼻-鼻窦炎(CRS)合并呼吸道合胞病毒(RSV)感染危险因素,并探讨鼻黏膜组织中白细胞介素(IL)-7、IL-33表达与RSV感染的关系。方法选取2018年6月-2021年6月在建德市第一人民医院确诊并行鼻内镜鼻窦手术治疗的285例CRS患者,根据患者鼻咽部分泌物RSV病毒检测结果分为RSV感染组82例和非RSV感染组203例,Logistic回归分析CRS患者合并RSV感染的危险因素。酶联免疫吸附试验(ELISA)检测鼻黏膜组织中IL-7、IL-33表达水平,采用受试者工作特征(ROC)曲线分析鼻窦黏膜IL-7、IL-33表达诊断RSV感染的临床价值。结果Logistic回归分析显示,吸烟、合并糖尿病、低蛋白血症均为CRS患者发生RSV感染的独立危险因素(P<0.05)。RSV感染组患者鼻黏膜组织IL-7、IL-33表达水平明显高于非RSV感染组(P<0.05);ROC曲线结果显示,IL-7、IL-33诊断CRS患者合并RSV感染的曲线下面积(AUC)分别为0.802、0.810。结论合并RSV感染CRS患者鼻黏膜组织IL-7、IL-33表达水平明显增加,且吸烟、合并糖尿病、低蛋白血症均为CRS患者发生RSV感染的独立危险因素。OBJECTIVE To analyze the risk factors for respiratory syncytial virus(RSV)infection in the patients with chronic rhino-sinusitis(CRS)and explore the association of expressions of interleukin(IL)-7,IL-33 in nasal mucosa tissues with the RSV infection.METHODS A total of 285 patients who were diagnosed with CRS and underwent endoscopic sinus surgery in Jiande First People′s Hospital from Jun 2018 to Jun 2021 were enrolled in the study and divided into the RSV infection group with 82 cases and the no RSV infection group with 203 cases according to the result of RSV test for nasopharyngeal secretions.Logistic regression analysis was performed for the risk factors for the RSV infection in the CRS patients.The expression levels of IL-7 and IL-33 in nasal mucosa tissues were detected by enzyme-linked immunosorbent assay(ELISA),and the clinical value of the expressions of nasal mucosa IL-7 and IL-33 in diagnosis of RSV infection was analyzed by means of receiver operating characteristic(ROC)curves.RESULTS Logistic regression analysis showed that smoking,complication with diabetes mellitus and hypoproteinemia were the independent risk factors for the RSV infection in the CRS patients(P<0.05).The expression levels of IL-7 and IL-33 in nasal mucosa tissues were remarkably higher in the RSV infection group than in the no RSV infection group.ROC curve analysis showed that the areas under curves(AUCs)of IL-7 and IL-33 were respectively 0.802 and 0.810 in diagnosis of RSV infection in the CRS patients.CONCLUSION The CRS patients complicated with RSV infection show remarkable rise of expression levels of IL-7 and IL-33 in nasal mucosa tissues.The smoking,complication with diabetes mellitus and hypoproteinemia are the independent risk factors for the RSV infection in the CRS patients.

关 键 词：慢性鼻-鼻窦炎 呼吸道合胞病毒 白细胞介素-7 白细胞介素-33 危险因素 

分 类 号：R765.4[医药卫生—耳鼻咽喉科]