痤疮颗粒辅助治疗对感染性痤疮患者外周血NF-κB炎症信号通路的影响  

Effect of acne granules as adjuvant therapy on peripheral blood NF-κB signaling pathways of patients with infectious acne

作　　者：侯文利 温杰 黄晓 赵旭明 高晓莉 李亚维 HOU Wen-li;WEN Jie;HUANG Xiao;ZHAO Xu-ming;GAO Xiao-li;LI Ya-wei(The First Affiliated Hospital of North University,Zhangjiakou,Hebei O75000,China)

机构地区：[1]北方学院附属第一医院皮肤科,河北张家口075000

出　　处：《中华医院感染学杂志》2023年第9期1380-1384,共5页Chinese Journal of Nosocomiology

基　　金：河北省卫生厅科研基金项目(20190895)。

摘　　要：目的研究痤疮颗粒联合水氧疗法+红光治疗对感染性痤疮患者外周血单个核细胞中核因子(NF)-κB炎症信号通路的影响。方法选取2019年6月-2021年6月北方学院附属第一医院皮肤科收治的110例感染性痤疮患者为研究对象,随机数表法分为研究组和对照组,每组55例,对照组予以苯扎氯氨稀释液水氧疗法+红光治疗,研究组在对照组基础上增加痤疮颗粒治疗,实时荧光定量PCR检测治疗前后血清NF-κB p50、p65 mRNA相对表达水平,并比较两组治疗前后皮肤生理指标、炎症因子水平及皮损个数,评估临床疗效和不良反应情况。结果治疗后,两组患者面部皮肤油脂含量、pH值以及角质层含水量均优于治疗前(P<0.05),且研究组各项皮肤生理指标优于对照组(P<0.05);治疗后,两组NF-κB p50、p65 mRNA相对表达量和炎症因子超敏C-反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)水平均低于治疗前(P<0.05),且研究组上述指标均低于对照组(P<0.05);治疗后,两组皮损(丘疹、粉刺、脓包)个数均少于治疗前(P<0.05),且研究组少于对照组(P<0.05);研究组临床总有效为96.36%,高于对照组的85.45%(P<0.05);治疗期间两组患者均未出现明显不良反应。结论痤疮颗粒辅助水氧疗法+红光治疗对感染性痤疮疗效确切,有利于改善患者皮肤生理指标,抑制NF-κB炎症信号通路的激活和炎性因子的释放或许为其可能机制。OBJECTIVE To observe the effect of acne granules combined with water-oxygen therapy and red light therapy on peripheral blood mononuclear cell nuclear factor(NF)-κB inflammatory signaling pathways of patients with infectious acne.METHODS A total of 110 patients with infectious acne who were treated in dermatology department of the First Affiliated Hospital of North University from Jun 2019 to Jun 2021 were recruited as the research subjects and were randomly divided into the study group and the control group,with 55 cases in each group.The control group was treated with benzalkonium chloride diluent water-oxygen therapy plus red light therapy,while the study group was given additional acne granules on basis of the treatment of the control group.The relative expression levels of serum NF-κB p50 and p65 mRNA were detected by real-time fluorescent quantitative PCR before and after treatment.The skin physiological indexes,inflammatory factors and number of skin lesions were compared between the two groups before and after the treatment.The clinical therapeutic effect and adverse reaction ns were evaluated.RESULTS The lipid content,pH value and water content of stratum corneum of facial skin were better after the treatment than before the treatment(P<0.05),and the facial physiological indexes of the study group were better than those of the control group(P<0.05).The relative expression levels of NF-κB p50 and p65 mRNA and the levels of inflammatory factors high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)of the two groups were remarkably lower after the treatment than before the treatment(P<0.05),and the above indexes of the study group were remarkably lower than those of the control group(P<0.05).The number of skin damage(papules,acne and pustules)of the two groups was remarkably less after the treatment than before the treatment(P<0.05),and the number of the skin damage of the study group was less than that of the control group(P<0.05).The total effective rate of

关 键 词：痤疮颗粒 苯扎氯氨稀释液 水氧疗法 红光治疗 感染性痤疮 核因子-κB炎症信号通路 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]