Salusin-α、sFlt-1及凝血指标与妊娠期高血压患者围产结局的关系  

Relationship between Salusin-α, sFlt-1 and coagulation indexes and perinatal outcomes in patients with gestational hypertension

作　　者：卫晓娟 段雅洁 李晓琴 宋对对 马萍 WEI Xiao-juan;DUAN Ya-jie;LI Xiao-qin(Department of Obstetrics,Yuncheng City Central Hospital,Yuncheng Shanxi 044000,China)

机构地区：[1]运城市中心医院产科,山西运城044000

出　　处：《临床和实验医学杂志》2023年第7期722-726,共5页Journal of Clinical and Experimental Medicine

基　　金：山西省卫生健康委科研课题(编号:2019163)。

摘　　要：目的探讨心血管活性肽α(Salusin-α)、可溶性Fms样酪氨酸激酶-1(sFlt-1)及凝血指标[凝血酶时间(TT)、凝血酶原时间(PT)、部分活化的凝血酶原时间(APTT)]与妊娠期高血压患者围产结局的关系。方法回顾性分析2021年1月至2022年1月运城市中心医院收治的87例妊娠期高血压患者作为研究对象,依据患者妊娠结局的不同分为不良妊娠组(n=46)与正常妊娠组(n=41)。其中不良妊娠包括早产(28周≤孕周<37周)、低体重儿(出生体重≤2500 g)、巨大儿(出生体重≥4000 g)及出生缺陷(包括先天性心脏病、脊柱裂、唇腭裂)。两组入院后均收集患者年龄、孕前体重指数、孕周、孕次、产次、文化程度、家庭月收入、有无家族高血压史、是否吸烟或被动吸烟各项资料。同时于患者入院后(治疗前)检测Salusin-α、sFlt-1及PT、APPT、TT。比较两组基线资料信息及实验室指标差异,通过受试者工作特征(ROC)分析Salusin-α、sFlt-1及PT、APPT、TT预测妊娠期高血压患者发生不良妊娠结局的价值。最后将单因素分析中有差异信息纳入Logistic回归性分析,行量化赋值,以妊娠结局为因变量,以孕周、文化程度、家庭收入、吸烟或被动吸烟、Salusin-α、sFlt-1及PT、APPT、TT为自变量,明确妊娠期高血压患者发生不良妊娠结局的危险因素。结果两组年龄、孕前体重指数、孕次、产次、家族高血压史比较,差异均无统计学意义(P>0.05);不良妊娠组吸烟或被动吸烟、不良妊娠组文化程度初中及以下、家庭月收入<3000元的患者占比显著高于正常妊娠组,差异均有统计学意义(P<0.05);不良妊娠组孕周较短,sFlt-1水平显著高于正常妊娠组,而Salusin-α、PT、APPT、TT水平显著低于正常妊娠组,差异均有统计学意义(P<0.05)。经ROC分析证实Salusin-α、sFlt-1及PT、APPT、TT均可用于妊娠期高血压患者发生不良妊娠结局的预测,曲线下面积分别为0.994、0.6Objective To investigate the relationship between cardiovascular active peptide-α(Salusin-α),soluble Fms like tyrosine kinase-1(sFlt-1)and coagulation indexes[thrombin time(TT),prothrombin time(PT),partially activated prothrombin time(APTT)]and perinatal outcomes in patients with gestational hypertension.Methods Eighty-seven patients with gestational hypertension admitted to Yuncheng City Central Hospital from January 2021 to January 2022 were retrospectively analyzed and divided into adverse pregnancy group(n=46)and normal pregnancy group(n=41)according to different pregnancy outcomes.Adverse pregnancies included preterm birth(28 weeks≤gestational age<37 weeks),low birth weight(birth weight≤2500 g),macrosomia(birth weight≥4000 g),and birth defects(including congenital heart disease,spina bifida,cleft lip and palate).The data of age,pre-pregnancy body mass index,gestational week,gestational parity,parity,education level,family monthly income,family history of hypertension,smoking or passive smoking were collected in both groups after admission.Salusin-α,sFlt-1,PT,APPT and TT were detected after admission(before treatment).The differences of baseline information and laboratory indicators between the two groups were compared.The value of Salusin-α,sFlt-1,PT,APPT and TT in predicting adverse pregnancy outcomes in patients with gestational hypertension was analyzed by receiver operating characteristic(ROC).Finally,the difference information in the univariate analysis was included in the Logistic regression analysis,and quantification was performed.Pregnancy outcome was the dependent variable,gestational age,education level,family income,smoking or passive smoking,Salusin-α,sFlt-1,PT,APPT,TT were the independent variables,and the risk factors of adverse pregnancy outcome in patients with gestational hypertension were identified.Results There were no statistically significant differences in age,pre-pregnancy body mass index,parity,parity and family history of hypertension between the two groups(P>0.05).The p

关 键 词：妊娠期高血压 妊娠结局 心血管活性肽-α 可溶性Fms样酪氨酸激酶-1 凝血功能 

分 类 号：R714.246[医药卫生—妇产科学]