机构地区:[1]秦皇岛市中医医院儿科,河北秦皇岛066600
出 处:《临床和实验医学杂志》2023年第8期870-875,共6页Journal of Clinical and Experimental Medicine
基 金:河北省中医药管理局科研计划项目(编号:2021383)。
摘 要:目的探讨加味麻杏石甘汤联合阿奇霉素序贯疗法治疗小儿支原体肺炎患儿的治疗效果及对血清炎症因子、氧化应激反应的影响。方法回顾性选取2020年1月至2021年6月在秦皇岛市中医医院接受治疗的104例患有小儿支原体肺炎的患儿作为研究对象,根据治疗方法的不同将患儿分成两组,每组各52例。对照组给予阿奇霉素序贯疗法治疗,观察组在对照组基础上给予加味麻杏石甘汤治疗。比较两组的疗效、肺炎支原体特异性IgM抗体(MP-IgM)转阴率及安全性,观察两组不同中医证侯分型的证候积分变化,检测两组炎症相关因子[超敏C反应蛋白(hs-CRP)、降钙素原(PCT)、D-二聚体(D-D)、可溶性细胞间黏附分子1(sICAM-1)、粒细胞集落刺激因子(G-CSF)、血清淀粉样蛋白(SAA)]及氧化应激因子[基质金属蛋白酶-9(MMP-9)、丙二醛、半胱氨酰白三烯(CysLTs)]的水平。结果观察组的治疗总有效率为92.31%,明显高于对照组(76.92%),差异有统计学意义(P<0.05)。治疗后,两组风热犯肺证、风寒袭肺证、痰热壅肺证及阴虚肺热证的积分均较治疗前降低,且观察组各积分均低于对照组,差异均有统计学意义(P<0.05)。治疗后,两组hs-CRP、PCT、D-D、sICAM-1、G-CSF、SAA、MMP-9、丙二醛、CysLTs水平均较治疗前降低,且观察组各指标均低于对照组,差异均有统计学意义(P<0.05)。观察组血清MP-IgM转阴率为90.38%,高于对照组(75.00%),差异有统计学意义(P<0.05)。观察组不良反应发生率为11.54%,与对照组(9.62%)比较,差异无统计学意义(P>0.05)。结论临床治疗小儿支原体肺炎采用加味麻杏石甘汤联合阿奇霉素序贯疗法能够提高治疗效果,其作用机制可能与改善炎症因子表达、降低氧化应激相关因子表达水平有关。Objective To observe the curative effect of Modified Maxing Shigan Decoction combined with azithromycin sequential therapy in the treatment of children with mycoplasma pneumonia and its influence on the serum inflammatory factors and oxidative stress response in children.Methods A total of 104 children with mycoplasma pneumonia who were admitted to the Qinhuangdao Hospital of Traditional Chinese Medicine from January 2020 to June 2021 were retrospectively selected as the research objects,and they were divided into two groups according to the different trentment methods,each group 52 cases.The children in the control group were treated with azithromycin sequential therapy,and the children in the observation group were treated with Modified Maxing Shigan Decoction on the basis of the control group.The efficacy,mycoplasma pneumonia-specific IgM antibody(MP-IgM)conversion rate and safety of the two groups were compared,the changes in the syndrome scores of the two groups of different TCM syndromes,and detect the levels of inflammation-related factors[hypersensitive C-reactive protein(hs-CRP),procalcitonin(PCT),D-dimer(D-D),human soluble intercellular adhesion molecule 1(sICAM-1),granulocyte colony-stimulating factor(G-CSF),serum amyloid protein(SAA)]and oxidative stress factors[matrix metalloproteinase-9(M)were detected in both groups(MP-9),malondialdehyde,human cysteyl leukotriene(CysLTs)]in the two groups were observed.Results The total effective rate of the observation group was 92.31%,which was significantly higher than that of the control group(76.92%),the differences was statistically significant(P<0.05).After treatment,the scores of wind-heat invading lung syndrome,wind-cold attacking lung syndrome,phlegm-heat obstructing lung syndrome,and yin deficiency lung-heat syndrome were lower than before treatment,and the scores of different TCM symptoms in the observation group after treatment were significantly lower than those in the control group,the differences were statistically significant(P<0.05).After treatmen
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...
正在载入数据...