卡维地洛联合胺碘酮治疗心律失常的效果及对血清hs-CRP水平、HR及LVEF的影响  

Effect of carvedilol combined with amiodarone on arrhythmia and its influences on serum hs-CRP level,HR and LVEF

作　　者：徐娜 梁栋楼[2] 王康 XU Na;LIANG Donglou;WANG Kang(the People's Hospital of Sishui County,Jining 273200;Jining No.1 People's Hospital,Jining 272000,China)

机构地区：[1]泗水县人民医院,山东济宁273200 [2]济宁市第一人民医院,山东济宁272000

出　　处：《临床医学研究与实践》2023年第15期41-44,共4页Clinical Research and Practice

摘　　要：目的探讨卡维地洛联合胺碘酮治疗心律失常的临床效果。方法选择我院2020年5月至2022年5月收治的116例心律失常患者,按随机数字表法将其分为对照组(n=58,胺碘酮)和研究组(n=58,卡维地洛联合胺碘酮)。比较两组的临床疗效、心率(HR)、左室射血分数(LVEF)及心率变异性参数、血清炎性指标及血流动力学指标。结果研究组的治疗总有效率显著高于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的HR低于治疗前,LVEF、24 h正常窦性心搏间期的标准差(SDNN)、24 h连续5 min窦性心搏间期标准差的均值(SDNN index)高于治疗前,且研究组优于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的超敏C反应蛋白(hs-CRP)、脂联素(APN)、半乳糖凝集素-3(Gal-3)和生长分化因子-15(GDF-15)水平低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。治疗后,两组的血浆黏度、纤维蛋白原(FIB)水平、红细胞沉降率低于治疗前,且研究组低于对照组,差异具有统计学意义(P<0.05)。结论卡维地洛联合胺碘酮治疗心律失常的效果显著,可有效改善患者的心率变异性参数及血流动力学指标,降低炎性因子水平,值得临床进一步推广应用。Objective To explore the clinical effect of carvedilol combined with amiodarone in the treatment of arrhythmia.Methods A total of 116 patients with arrhythmia admitted in our hospital from May 2020 to May 2022 were selected and divided into control group(n=58,amiodarone)and study group(n=58,carvedilol combined with amiodarone)according to the random number table method.The clinical efficacy,heart rate(HR),left ventricular ejection fraction(LVEF)and heart rate variability parameters,serum inflammatory indexes and hemodynamic indexes were compared between the two groups.Results The total effective rate of treatment in the study group was significantly higher than that in the control group,and the difference was statistically significant(P<0.05).After treatment,the HR in the two groups was lower than that before treatment,the LVEF,standard deviation of normal number of intervals(SDNN)and average of standard deviation of 5 min normal number of intervals(SDNN index)were higher than those before treatment,and those in the study group were better than the control group,the differences were statistically significant(P<0.05).After treatment,the levels of high sensitive C-reactive protein(hs-CRP),adiponectin(APN),galectin-3(Gal-3)and growth differentiation factor-15(GDF-15)in the two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).After treatment,the plasma viscosity,fibrinogen(FIB)level and erythrocyte sedimentation rate in the two groups were lower than those before treatment,and those in the study group were lower than the control group,the differences were statistically significant(P<0.05).Conclusion Carvedilol combined with amiodarone is effective in the treatment of arrhythmia,it can effectively improve the heart rate variability parameters and hemodynamic indexes of patients,reduce the levels of inflammatory factors,which is worthy of further clinical promotion and application.

关 键 词：心律失常 卡维地洛 胺碘酮 

分 类 号：R541.7[医药卫生—心血管疾病]