布地奈德雾化吸入+硫酸镁治疗小儿重症哮喘急性发作的临床效果及对气道重塑的影响  

Clinical effect of budesonide atomization inhalation+magnesium sulfate in the treatment of acute attack of severe asthma in children and its influence on airway remodeling

作　　者：孙蕾 曹雯 陈涛[3] SUN Lei;CAO Wen;CHEN Tao(Qishan County Hospital,Baoji 722400;Xi'an Chengbei Hospital,Xi'an 710021;Shangluo Central Hospital,Shangluo 725000,China)

机构地区：[1]岐山县医院,陕西宝鸡722400 [2]西安城北医院,陕西西安710021 [3]商洛市中心医院,陕西商洛725000

出　　处：《临床医学研究与实践》2023年第15期69-72,共4页Clinical Research and Practice

摘　　要：目的探究布地奈德雾化吸入+硫酸镁治疗小儿重症哮喘急性发作的临床效果。方法选择2018年3月至2021年3月本院收治的96例重症哮喘急性发作患儿为研究对象,遵循数字随机表法将其分为参照组(n=48,常规对症治疗)和研究组(n=48,在常规对症治疗基础上开展布地奈德雾化吸入+硫酸镁治疗)。比较两组的治疗效果。结果研究组的治疗总有效率高于参照组(P<0.05)。两组的不良反应总发生率比较,差异无统计学意义(P>0.05)。治疗后,研究组的管壁面积百分比(WA)、总面积(TA)、管腔面积(LA)小于参照组(P<0.05)。治疗后,研究组的基质金属蛋白酶-9(MMP-9)及基质金属蛋白酶抑制剂-1(TIMP-1)水平低于参照组(P<0.05)。治疗后,研究组的气道阻力(Raw)、临床症状评分低于参照组,最大通气量(MVV)、肺活量(VC)、第1秒用力呼气肺容积(FEV_(1))大于参照组(P<0.05)。结论布地奈德雾化吸入+硫酸镁治疗小儿重症哮喘急性发作可提升疗效,改善气道重塑、肺功能指标,且安全性高,值得推广应用。Objective To explore the clinical effect of budesonide atomization inhalation+magnesium sulfate in the treatment of acute attack of severe asthma in children.Methods From March 2018 to March 2021,96 children with acute attack of severe asthma in our hospital were selected as the research objects.According to the digital random table method,the children were divided into reference group(n=48,routine symptomatic treatment)and study group(n=48,budesonide atomization inhalation+magnesium sulfate treatment on the basis of routine symptomatic treatment).The therapeutic effects of the two groups were compared.Results The total effective rate of treatment in the study group was higher than that in the reference group(P<0.05).There was no significant difference in the total incidence of adverse reactions between the two groups(P>0.05).After treatment,the wall area(WA),total area(TA)and lumen area(LA)of the study group were smaller than those of the reference group(P<0.05).After treatment,the levels of matrix metalloproteinase-9(MMP-9)and tissue inhibitor of metalloproteinase-1(TIMP-1)in the study group were lower than those in the reference group(P<0.05).After treatment,the airway resistance(Raw)and the clinical symptom score of the study group were lower than those of the reference group,and the maximum ventilation volume(MVV),vital capacity(VC)and forced expiratory volume in the first second(FEV_(1))were greater than those of the reference group(P<0.05).Conclusion Budesonide atomization inhalation+magnesium sulfate in the treatment of acute attack of severe asthma in children can improve the curative effect,ameliorate airway remodeling and lung function indexes,and has high safety,which is worthy of promotion and application.

关 键 词：布地奈德 雾化吸入 硫酸镁 小儿 重症哮喘急性发作 气道重塑 

分 类 号：R725.6[医药卫生—儿科]