PPIA基因rs6850位点多态性与冠心病合并2型糖尿病的关系  

Association of PPIA gene rs6850 locus polymorphism with coronary heart disease combined with type 2 diabetes mellitus

作　　者：尹明月 李秋菊 王宁[1] YIN Mingyue;LI Qiuju;WANG Ning(Department of Internal MedicineⅡ,The First Affiliated Hospital of Xinjiang Medical University,Urumqi 830011,China)

机构地区：[1]新疆医科大学第一附属医院综合内二科,乌鲁木齐830011

出　　处：《山东医药》2023年第14期25-28,共4页Shandong Medical Journal

基　　金：省部共建中亚高发病成因与防治国家重点实验室项目(03020102)。

摘　　要：目的探讨PPIA基因rs6850位点多态性与冠心病(CAD)患者合并2型糖尿病(T2DM)的关系。方法选取CAD、CAD合并T2DM患者各100例,采集患者静脉血,采用直接测序法检测PPIA基因rs6850位点的基因多态性。比较两组基因型和等位基因频率分布情况,对比不同基因型患者的临床资料,采用Logistic回归分析冠心病患者发生2型糖尿病的影响因素。结果PPIA基因rs6850位点基因型、等位基因、显性模型和隐性模型在CAD+T2DM组和CAD组间的分布差异无统计学意义(P均>0.05)。GA基因型携带者BMI较AA、GG基因型携带者升高(P均<0.05)。调整混杂因素后,Logistic回归分析显示,GG、GA、AA三种基因型均不是冠心病患者发生2型糖尿病的影响因素(P均>0.05)。结论PPIA基因rs6850位点多态性与冠心病合并2型糖尿病患者的遗传易感性无关。Objective To investigate the association of PPIA gene rs6850 locus polymorphism with type 2 diabe⁃tes mellitus(T2DM)in patients with coronary artery disease(CAD).Methods One hundred patients with CAD and one hundred patients with CAD combined with T2DM were selected.Venous blood was collected from the patients and the gene polymorphism at the rs6850 locus of the PPIA gene was detected by direct sequencing.The genotypes and allele fre⁃quency distribution of the two groups were compared,the clinical data of patients with different genotypes were compared,and the factors influencing the development of T2DM in patients with CAD were analyzed by Logistic regression.Results There were no statistically significant differences in the distribution of PPIA gene rs6850 locus genotypes,alleles,domi⁃nant or recessive models between the CAD+T2DM and CAD groups(all P>0.05).BMI was elevated in GA genotype carri⁃ers compared with AA and GG genotype carriers(all P<0.05).After adjusting for confounders,Logistic regression analy⁃sis showed that none of the three genotypes GG,GA,and AA were influential factors in the development of T2DM in pa⁃tients with CAD(all P>0.05).Conclusion PPIA gene rs6850 locus polymorphism was not associated with genetic sus⁃ceptibility in patients with CAD combined with T2DM.

关 键 词：单核苷酸多态性 PPIA基因 2型糖尿病 冠状动脉粥样硬化性心脏病 

分 类 号：R541.4[医药卫生—心血管疾病] R587.1[医药卫生—内科学]