孕妇Hcy与HDCP及母婴不良妊娠结局的关系  

作　　者：葛玲燕 邱二娟 宋李桃 

机构地区：[1]浙江中医药大学附属杭州市中医院,310005

出　　处：《浙江临床医学》2023年第4期527-528,532,共3页Zhejiang Clinical Medical Journal

基　　金：浙江省中医药科技计划项目(2022ZA106)。

摘　　要：目的探讨孕妇血同型半胱氨酸(Hcy)水平与妊娠期高血压疾病(HDCP)和母婴不良妊娠结局的关系。方法选取2017年2月至2022年2月待产的HDCP患者102例为观察组,选取同期待产孕妇90例为正常组,比较两组血清Hcy、超敏C反应蛋白(hsCRP)、Ca^(2+)、叶酸及血尿酸(UA)水平,根据观察组Hcy中位值,将高于中位值的作为HM组,低于中位值的作为LM组,分析Hcy高低与观察组不良妊娠结局关系,采用Pearson法进行相关性分析,Logistic多因素法分析影响HDCP妊娠结局的因素。结果HDCP组孕妇Hcy、hsCRP、UA水平显著高于正常组,Ca^(2+)、叶酸水平低于正常组(P<0.05),HDCP组Hcy高于中位值的HM组妊娠结局明显高于LM组,两组不良妊娠结局比较(P<0.05);Hcy与hsCRP、UA呈正相关,与Ca^(2+)、叶酸水平呈负相关;Logistic多因素法分析Hcy、hsCRP、UA为影响HDCP妊娠结局危险因素。结论HDCP患者Hcy水平较正常孕妇偏高,Hcy升高与HDCP母婴不良妊娠结局相关。Objective To investigate relationship between homocysteine and hypertensive diseases in adverse pregnancy outcome.Methods 102 Pregnant women of Hypertensive disorders of pregnancy(HDCP)from February 2017 to February 2022 were selected as the observation group,90 pregnant women were selected as the normal group.Serum levels of Hcy,hsCRP,Ca^(2+),folic acid and UA were compared between the two groups.According to median Hcy in the observation group,those were higher than the median Hcy were chosen as the HM group,those were lower were chosen as the LM group.The relationship between Hcy level and adverse pregnancy outcome in the observation group was analyzed.Results The levels of Hcy,hsCRP and UA in the group of HDCP were higher than that of the normal group,the level of Ca^(2+) and folic acid were lower than that of the normal group(P<0.05).The outcome of pregnancy in HM group with Hcy which was higher than the median value in HDCP group was higher than that in the LM group.The adverse pregnancy outcome between two groups were compared(P<0.05).Hcy was positively correlated with hsCRP and UA,but was negatively correlated with Ca^(2+) and folic acid.The method of Logistic showed that Hcy,hsCRP and UA were risk factor for pregnancy outcome of HDCP.Conclusion The level of Hcy in patients with HDCP is higher than normal pregnant women,and the increase of Hcy is associated with adverse pregnancy outcomes and infants with HDCP.

关 键 词：妊娠期高血压疾病 同型半胱氨酸 妊娠结局 

分 类 号：R714[医药卫生—妇产科学]