两性离子材料在生物化工领域的应用  

Application of Zwitterionic Materials in Biochemical Industry

作　　者：耿逸婉 阳俊[1] 武燕月 邱鑫雨 王文丽[4] 卢治国 张欣[1] GENG Yiwan;YANG Jun;WU Yanyue;QIU Xinyu;WANG Wenli;LU Zhiguo;ZHANG Xin(National Key Lab of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;University of Chinese Academy of Sciences,Beijing 100049,China;Shandong First Medical University,Tai'an 271000,China;Hebei Medical University,Shijiazhuang 050017,China)

机构地区：[1]中国科学院过程工程研究所,生化工程国家重点实验室,北京100190 [2]中国科学院大学,北京100049 [3]山东第一医科大学,山东泰安271000 [4]河北医科大学,河北石家庄050017

出　　处：《化学反应工程与工艺》2023年第2期166-182,共17页Chemical Reaction Engineering and Technology

基　　金：国家自然科学基金(21875254,52073287,22075289,32071391)。

摘　　要：两性离子材料是一类具有相同数量阳离子和阴离子官能团、整体呈电中性的材料。两性离子聚合物能够通过与水分子之间形成超强水化层抵抗蛋白质等污染物的表面吸附,因此具有突出的抗污特性。此外,两性离子材料还具有黏附性、抗冻性、药物增溶性、离子选择性等性能,已广泛应用于生物医药、工业生产等领域。本文首先总结了两性离子材料的抗污特性,介绍其在抗蛋白、抗细菌、抗病毒吸附方面的应用,接着以医用传感器、药物递送和分离膜为生物化工领域的代表方向,介绍两性离子材料的抗污及其他应用,最后讨论了发展两性离子材料存在的问题与挑战,展望了两性离子材料作为一类新型功能化材料的应用前景。Zwitterionic structure is electrically neutral with the same number of cationic and anionic functional groups.Materials with zwitterionic group exhibit outstanding anti-fouling characteristics due to the super hydration layer formed between water molecules.In addition,zwitterionic materials also have properties such as adhesion,frost resistance,enhanced drug solubility and ion selectivity,which extend the application to biomedical,industrial production and other fields.This paper focused on the application of zwitterionic materials in biochemical industry.Firstly,the anti-fouling property of zwitterionic materials was summarized from the perspective of anti-fouling objects protein,bacteria and virus.Secondly,the application progress in medical sensors,drug delivery and separation membranes were introduced.Finally,the problems and challenges in the development of zwitterionic materials were discussed,and the application prospects of zwitterionic materials were prospected.

关 键 词：两性离子材料 抗污特性 医用传感器 药物递送 分离膜 

分 类 号：O631[理学—高分子化学] TB34[理学—化学]