微血流成像联合超声造影诊断猪肾创伤伴活动性出血的实验研究  

Experimental study on micro-flow imaging combined with contrastenhanced ultrasound in the diagnosis of active bleeding from renal trauma in pigs

作　　者：朱连华 费翔[1] 韩鹏 姜波[1] 罗渝昆[1] ZHU Lianhua;FEI Xiang;HAN Peng;JIANG Bo;LUO Yukun(Department of Ultrasound Diagnosis,the First Medical Center,Chinese PLA General Hospital,Beijing 100853,China)

机构地区：[1]解放军总医院第一医学中心超声诊断科,北京市100853

出　　处：《临床超声医学杂志》2023年第5期335-339,共5页Journal of Clinical Ultrasound in Medicine

基　　金：国家自然科学青年基金项目(82001817)。

摘　　要：目的探讨微血流成像(MFI)联合超声造影(CEUS)在猪肾创伤伴活动性出血诊断及定位中的应用价值。方法选取健康巴马小型猪10只,建立肾创伤伴活动性出血模型。模型建立成功后进行CEUS及MFI检查,比较MFI联合CEUS与CEUS诊断及定位活动性出血的准确率;应用MFI联合CEUS测量活动性出血受损血管破口内径。结果1只巴马小型猪由于麻醉原因在实验过程中意外死亡,剩余9只巴马小型猪共成功构建18处肾创伤伴活动性出血灶。CEUS与MFI联合CEUS诊断活动性出血的准确率分别为77.78%、94.44%,二者比较差异无统计学意义;CEUS与MFI联合CEUS定位活动性出血的准确率分别为55.56%、94.44%,二者比较差异有统计学意义(P<0.05)。MFI联合CEUS测得活动性出血受损血管破口内径为1.54~2.42 mm,平均(1.94±0.29)mm。结论MFI联合CEUS能清晰显示猪肾创伤灶内受损血管,准确诊断活动性出血,且定位活动性出血的能力优于CEUS。Objective To explore the application value of micro flow-imaging(MFI)combined with contrastenhanced ultrasound(CEUS)in the diagnosis and localization of active bleeding from renal trauma in pigs.Methods The model of renal trauma with active bleeding was established in 10 healthy Bama miniature pigs.CEUS and MFI were performed after the model was established.The accuracy of CEUS and MFI combined with CEUS in the diagnosis and localization of active bleeding from renal trauma were compared.The inner diameter of ruptured vessels in renal trauma with active bleeding was measured by MFI combined with CEUS.Results One Bama miniature pig died unexpectedly due to anesthesia during the experiment,and the remaining 9 Bama miniature pigs successfully established 18 renal trauma with active bleeding.The accuracy of CEUS and MFI combined with CEUS in the diagnosis of active bleeding were 77.78%and 94.44%,respectively.The difference was not statistically significant.The accuracy of CEUS and MFI combined with CEUS in the localization of active bleeding were 55.56%and 94.44%,respectively.The difference was statistically significant(P<0.05).The inner diameter of ruptured vessels in renal trauma with active bleeding measured by MFI combined with CEUS was 1.54~2.42 mm,with an average of(1.94±0.29)mm.Conclusion MFI combined with CEUS can clearly display the damaged vessels of renal trauma with active bleeding,accurately diagnose active bleeding,and have a better ability to locate the site of active bleeding than CEUS.

关 键 词：超声检查 造影剂 微血流成像 肾创伤 活动性出血 定位诊断 巴马小型猪 

分 类 号：R445.1[医药卫生—影像医学与核医学]