辣木叶及其有效成分抗高脂血症药理作用研究进展  

Research progress of anti-hyperlipidemia effects of Moringa oleifera leaves and its active components

作　　者：杨卓凡 宣攒威 罗浩鑫 郑智彬 朱锦鸿 周红祖 黄庆宝[2] 余惠旻 YANG Zhuofan;XUAN Zanwei;LUO Haoxin;ZHENG Zhibin;ZHU Jinhong;ZHOU Hongzu;HUANG Qingbao;YU Huimin(School of Medicine,Shenzhen University,Shenzhen 518060,China;Shenzhen Chinese Medicine Hospital,Shenzhen 518020,China)

机构地区：[1]深圳大学医学部,广东深圳518060 [2]深圳市中医院,广东深圳518020

出　　处：《药物评价研究》2023年第4期911-916,共6页Drug Evaluation Research

基　　金：广东省大学生创新创业训练计划(S202210590113);深圳市基础研究面上项目(JCYJ20220531102208019);深圳市药学会医院药学研究基金(恒瑞基金)(SZ2022A25);深圳大学聚徒+学术项目(803-0000311684)。

摘　　要：辣木叶来源于热带植物辣木Moringa oleifera,以叶入药,具有良好的生理活性。现代研究显示辣木叶含有丰富的黄酮、多糖、多酚、生物碱等功能成分,具有明确的抗氧化、抗菌、降糖、抗高脂血症等药理作用。辣木叶及其有效成分可能通过抑制脂质过氧化、抑制胰脂肪酶活性、抑制α-葡萄糖苷酶活性、诱导棕色脂肪组织生成、提高胆汁酸结合能力等途径达到抗高脂血症作用。综述辣木叶及其有效成分抗高脂血症药理作用的研究进展,以期为利用该药用植物资源开发新药提供依据。Moringa oleifera leaves are derived from Moringa oleifera Lam.and used as medicine.Modern studies have shown that M.oleifera leaves are rich in functional components such as flavonoids,polysaccharides,polyphenols and alkaloids,and have defined pharmacological effects such as antioxidant,antibacterial,hypoglycemic and anti-hyperlipidemia.M.oleifera leaves and its active components may achieve the anti-hyperlipidemia effect by inhibiting lipid peroxidation,inhibiting the activity of pancreatic lipase,inhibiting the activity ofα-glucosidase,inducing the formation of brown adipose tissue,and improving the bile acid binding ability.The research progress of the pharmacological effects of M.oleifera leaves and its active components on anti-hyperlipidemia are reviewed,in order to provide a basis for the development of new drugs for hyperlipidemia using the medicinal plant resources.

关 键 词：辣木叶 抗高脂血症 抑制脂质过氧化 抑制胰脂肪酶活性 抑制α-葡萄糖苷酶 

分 类 号：R285.5[医药卫生—中药学]