齿痛消炎灵颗粒联合浓替硝唑含漱液治疗慢性牙周炎的临床研究  

Clinical study on Chitong Xiaoyanling Granules combined with Concentrated Tinidazole Gargles in treatment of chronic periodontitis

作　　者：张帆[1] 马丽芳 ZHANG Fan;MA Li-fang(Department of Stomatology,Hospital of Northwestern Polytechnical University,Xi’an 710072,China;Department of Dentistry and Endodontics,Stomatological Hospital of Air Force Medical University(State Key Laboratory ofMilitary Stomatology,National Clinical Medical Research Center for Stomatology,Shaanxi Province Key Laboratory ofStomatology),Xi’an 710032,China)

机构地区：[1]西北工业大学医院口腔科,陕西西安710072 [2]空军军医大学口腔医院(军事口腔医学国家重点实验室,国家口腔疾病临床医学研究中心,陕西省口腔医学重点实验室)牙体牙髓病科,陕西西安710032

出　　处：《现代药物与临床》2023年第4期919-923,共5页Drugs & Clinic

摘　　要：目的 探讨齿痛消炎灵颗粒联合浓替硝唑含漱液治疗慢性牙周炎的临床疗效。方法 选取2019年8月—2022年5月在西北工业大学医院就诊的112例慢性牙周炎患者,按照随机数字表法将所有患者分为对照组和治疗组,每组各56例。对照组含漱浓替硝唑含漱液,1 min/次,3次/d。治疗组在对照组基础上温水冲服齿痛消炎灵颗粒,1袋/次,3次/d。两组患者连续治疗1个月。观察两组的临床疗效,比较两组口腔健康状态、牙周指标和龈沟液因子水平。结果 治疗后,治疗组的总有效率为89.29%,明显高于对照组的总有效率75.00%,差异具有统计学意义(P<0.05)。治疗后,两组的口腔健康影响程度量表(OHIP-49)评分明显降低(P<0.05),治疗组OHIP-49评分明显低于对照组(P<0.05)。治疗后,两组的菌斑指数、牙龈指数、附着丧失明显降低(P<0.05),且治疗组患者菌斑指数、牙龈指数、附着丧失低于对照组,差异有统计学意义(P<0.05)。治疗后,两组的龈沟液五聚素3(PTX3)、基质金属蛋白酶8(MMP-8)、破骨细胞分化因子(RANKL)水平明显降低(P<0.05);治疗组的龈沟液PTX3、MMP-8、RANKL水平低于对照组,差异有统计学意义(P<0.05)。结论齿痛消炎灵颗粒联合浓替硝唑含漱液治疗慢性牙周炎的疗效确切,能改善口腔健康状态和牙周指标,降低炎症损伤。Objective To investigate the clinical effect of Chitong Xiaoyanling Granules combined with Concentrated Tinidazole Gargles in treatment of chronic periodontitis.Methods Patients(112 cases)with chronic periodontitis in Hospital of Northwestern Polytechnical University from August 2019 to May 2022 were divided into control and treatment groups according to the random number table method,and each group had 56 cases.Patients in the control group gargle with tinidazole gargle,1 min each time,three times daily.Patients in the treatment group were po administered with Chitong Xiaoyanling Granules on the basis of the control group,1 bag/time,three times daily.Patients in two groups were treated for 1 month.After treatment,the clinical efficacies were evaluated,and the oral health status,periodontal indicators,and gingival crevicular fluid factor levels in two groups were compared.Results After treatment,the total effective rate of the treatment group was 89.29%,which was significantly higher than that of the control group(75.00%),with a statistically significant difference(P<0.05).After treatment,OHIP-49 score of two groups were significantly decreased(P<0.05),and OHIP-49 score of the treatment group was significantly lower than that of the control group(P<0.05).After treatment,the plaque index,gingival index,and attachment loss of two groups were significantly decreased(P<0.05),and the plaque index,gingival index and attachment loss of the treatment group were lower than those of the control group(P<0.05).After treatment,the levels of PTX3, MMP-8, and RANKL in gingival crevicular fluid of two groups were significantly decreased (P < 0.05). The levels of PTX3, MMP-8, and RANKL in gingival crevicular fluid in the treatment group were lower than those in the control group (P < 0.05). Conclusion Chitong Xiaoyanling Granules combined with Concentrated Tinidazole Gargles has clinical curative effect in treatment of chronic periodontitis, can improve oral health and periodontal indicators, and reduce inflammatory and injury.

关 键 词：齿痛消炎灵颗粒 浓替硝唑含漱液 慢性牙周炎 OHIP-49评分 菌斑指数 PTX3 MMP-8 RANKL 

分 类 号：R988.2[医药卫生—药品]