淫羊藿苷改善中枢神经系统疾病的研究进展  

Research progress on icariin in improving central nervous system diseases

作　　者：司玉芳 严少普[1] 王文博 SI Yu-fang;YAN Shao-pu;WANG Wen-bo(Department of Life Sciences,College of Chemistry and Chemical Engineering,Xianyang Normal University,Xianyang 712000,China)

机构地区：[1]咸阳师范学院化学与化工学院生命科学系,陕西咸阳712000

出　　处：《现代药物与临床》2023年第4期988-994,共7页Drugs & Clinic

基　　金：国家自然科学基金资助项目(31872175);咸阳师范学院科研计划面上项目(XSYK22002)。

摘　　要：淫羊藿苷是淫羊藿中主要活性成分,具有抗肿瘤、抗炎、增强免疫、抗肝毒性、抗氧化等多种药理活性。淫羊藿苷可通过多靶点、多途径对中枢神经系统疾病产生保护作用,如淫羊藿苷具有抗抑郁作用,对阿尔茨海默病、帕金森病、缺血性脑卒中、多发性硬化具有保护作用。为了进一步扩大淫羊藿苷在临床治疗中的应用,综述了淫羊藿苷改善中枢神经系统疾病及其作用机制。Icariin is one of main active components in Epimedii Folium,which has various pharmacological activities,such as antitumor,anti-inflammatory,immune enhancement,anti-hepatotoxicity,antioxidant,etc.Icariin can protect central nervous system diseases through multiple targets and pathways.Icariin has antidepressant effects and protective effects on Alzheimer's disease,Parkinson's disease,ischemic stroke,and multiple sclerosis.In order to further expand the application of icariin in clinical application,this article reviews the improvement of central nervous system diseases by icariin and its mechanism.

关 键 词：淫羊藿苷 抗抑郁作用 阿尔茨海默病 帕金森病 缺血性脑卒中 多发性硬化 

分 类 号：R971[医药卫生—药品]