射频微针联合超分子水杨酸改善面部光老化的效果  

Effect of microneedle radiofrequency combined with supramolecular salicylic acid on facial photoaging

作　　者：蒋兰兰 葛兰 李垚莹 梁高澎 宋志强 Jiang Lanlan;Ge Lan;Li Yaoying;Liang Gaopeng;Song Zhiqiang(Department of Dermatology,the First Affiliated Hospital of Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学第一附属医院皮肤科,重庆400038

出　　处：《中华医学美学美容杂志》2023年第2期120-125,共6页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：国家自然科学基金(82073442);重庆市科卫联合项目(2023MSXM078)。

摘　　要：目的探讨射频微针联合超分子水杨酸改善面部光老化的有效性及安全性。方法选取2021年6月至2022年3月于陆军军医大学第一附属医院皮肤科门诊接受治疗的中度面部皮肤光老化女性患者30例,年龄30~50(39.4±4.1)岁。分为联合治疗组和射频微针组各15例,联合治疗组用射频微针联合超分子水杨酸治疗,射频微针组仅用射频微针治疗,并于治疗后3、7、14、28 d和3个月进行随访。用VISIA、皮肤生理相关指标及患者满意度等比较两组患者治疗结果。结果治疗后3个月,联合治疗组患者的皮肤毛孔(11.98±2.14比15.54±1.52)、棕色斑(12.40±1.85比15.84±1.42)、紫质(6.74±0.87比11.20±1.70)、皮肤生理状态[经表皮失水量(11.84±1.80比13.09±1.96)g/(h·m)^(2),角质层含水量(84.91±2.86比80.29±3.58)%,黑素指数(110.07±15.02比122.30±9.97),红斑指数(220.43±19.69比236.30±16.55)]、弹性(75.98±3.94比69.89±3.58)、表皮厚度(1401.33±178.43比1217.13±139.77)、肤色改善程度(有效率86.7%比40.0%)及患者满意度(93.3%比67.0%)均显著优于射频微针组,差异均有统计学意义(均P<0.05)。联合治疗组患者的中重度红斑(40.0%比86.7%)及水肿反应(26.7%比80.0%)明显低于射频微针组,差异均有统计学意义(均P<0.05)。治疗后两组均无色素沉着。结论射频微针联合超分子水杨酸治疗面部光老化的效果肯定、安全性好,值得临床应用。Objective To explore the efficacy and safety of microneedle radiofrequency combined with supramolecular salicylic acid in improving facial photoaging.Methods Thirty patients treated for facial photoaging were randomly divided into the combined treatment group and the microneedle radiofrequency group.All patients were female,aged between 30 and 50 years,with an average age of(39.4±4.1)years.The combined treatment group was treated with microneedle radiofrequency combined with supramolecular salicylic acid,and the Microneedle radiofrequency group was treated with microneedle radiofrequency alone.The patients were followed up 3 days,7 days,14 days,28 days and 3 months after treatment.The results of VISIA,skin physiology and patients'satisfaction were used to compare the two groups of patients after treatment.Results After 3 months of treatment,the skin pores(11.98±2.14 vs.15.54±1.52),brown spots(12.40±1.85 vs.15.84±1.42),ultraviolet spots(6.74±0.87 vs.11.20±1.70),skin physiological status(transepidermal water loss):11.84±1.80 vs 13.09±1.96 g/(h·m)^(2),stratum corneum water content:84.91±2.86%vs 80.29±3.58%,melanin index:110.07±15.02 vs.122.30±9.97,erythema index:220.43±19.69 vs.236.30±16.55),elasticity(75.98±3.94 vs.69.89±3.58),epidermal thickness(1401.33±178.43 vs.1217.13±139.77),skin color improvement(effective rate 86.7%vs.40.0%)and patients'satisfaction(total satisfaction was 93.3%vs 67.0%)in the combined treatment group were significantly superior than those in the microneedle radiofrequency group,and the differences were statistically significant(P<0.05).The reaction of moderate and severe erythema(the incidence rate 40.0%vs.86.7%)and edema(the incidence rate 26.7%vs.80.0%)in the combined treatment group was also significantly lower than that in the microneedle radiofrequency group(P<0.05).No adverse pigmentation was reported in both groups after treatment.Conclusions The combination of microneedle radiofrequency and supramolecular salicylic acid in the treatment of facial photoaging has de

关 键 词：光 光老化 射频微针 超分子水杨酸 治疗结果 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]