132例化妆品皮肤不良反应患者的临床特征  

Clinical characteristics of patients with skin adverse reactions of cosmetics: report of 132 cases

作　　者：平贯芳 程赛 熊万成 郗玉玲[1] 卢乙众[1] 邓智建[1] Ping Guanfang;Cheng Sai;Xiong Wancheng;Lu Yizhong;Deng Zhijian(Department of Pharmacy,the First Affiliated Hospital of Xinciang Medical University,Xinciang 453100,China;Department of Dermatology,the First Affiliated Hospital of Xinciang Medical University,Xinciang 453100,China;Department of General Surgery,the First Affiliated Hospital of Xinciang Medical University,Xinxiang 453100,China)

机构地区：[1]新乡医学院第一附属医院药学部,新乡453100 [2]新乡医学院第一附属医院皮肤科,新乡453100 [3]新乡医学院第一附属医院普外科,新乡453100

出　　处：《中华医学美学美容杂志》2023年第2期138-141,共4页Chinese Journal of Medical Aesthetics and Cosmetology

基　　金：河南省医学科技攻关项目(201702129);河南省联合共建项目(LHGJ202105291)。

摘　　要：目的探讨化妆品皮肤不良反应的临床特征。方法2021年1—12月就诊于新乡医学院第一附属医院皮肤科的化妆品不良反应患者132例,男5例、女127例,年龄2~66(34.0±13.1)岁。收集患者个人信息、病史记录、临床症状、化妆品信息及相关实验室检查结果等。结果132例患者化妆品皮肤不良反应中,接触性皮炎114例,占86.4%;主要部位为面部(96.5%)。患者自觉症状主要为瘙痒、灼热(83.9%),其次为疼痛、干燥和紧绷感,主要皮损形态为红斑、丘疹(92.9%)。可疑致敏化妆品主要为护肤类(45例)和美白祛斑类(30例)。7例患者选择进行斑贴试验,除1例患者试验结果阴性外,其余均为阳性。结论化妆品接触性皮炎是最常见的化妆品皮肤病,多见于中青年女性;斑贴试验仍是诊断化妆品接触性皮炎的重要检查手段。Objective To analyse the skin clinical characteristics of adverse reactions to cosmetic products.Methods A total of 132 patients suffered with the skin adverse reactions of cosmetics were collected in the Department of Dermatology in the First Affiliated Hospital of Xinxiang Medical University from January 2021 to December 2021.There were 5 males and 127 females,aged 2-66(34.0±13.1)years.and the personal information,medical records,clinical characteristics and the cosmetic information as well as laboratory results were collected.Results The major types of adverse reactions to cosmetic products were contact dermatitis(86.4%).Head was the most commonly affected site,The most common symptoms were pruritus and burning sensation(83.9%),and sores,dryness,tightness of the skin,and the common skin lesions included erythema and papula(92.9%).Suspected cosmetics were mostly skin care products(45 cases)and freckle removing products(30 cases).Only 7 patients accepted patch tests,1 case had negative results and others were all tested positive.Conclusions Adverse drug reactions affect young and middle-aged women mostly.Contact dermatitis is the most common adeverse reaction to cosmetic products and the patch test is still the most effective method in helping diagnosing contact dermatitis to cosmetic products.

关 键 词：化妆品 接触性皮炎 斑贴试验 疾病特征 皮肤不良反应 

分 类 号：R758.2[医药卫生—皮肤病学与性病学]