桃核承气汤化学成分、药理作用、临床应用研究进展及质量标志物预测分析  

Research progress of chemical composition,pharmacological effects and clinical applications of Taohe Chengqi Decoction and prediction and analysis of its Q-marker

作　　者：蔡磊 李现林[2] 陈祖闯 Cai Lei;Li Xianlin;Chen Zuchuang(Henan University of Chinese Medicine,Zhengzhou 450000,China;Department of Orthopedics and Traumatology,the First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 450000,China)

机构地区：[1]河南中医药大学,郑州450000 [2]河南中医药大学第一附属医院骨伤科,郑州450000

出　　处：《国际中医中药杂志》2023年第5期648-652,共5页International Journal of Traditional Chinese Medicine

基　　金：河南省中医药科学研究专项课题项目(2018ZY2130)。

摘　　要：桃核承气汤是泻热逐瘀的经典名方,具有抗炎、免疫调节、改善血液流变学、改善肾间质纤维化等药理作用,临床常用于治疗内科、骨科及妇产科疾病。总结分析近年桃核承气汤化学成分、药理作用及临床应用研究文献,在此基础上参照质量标志物(Q-marker)“五原则”对其Q-marker进行预测分析,认为苦杏仁苷、肉桂酸、桂皮醛、大黄酸、大黄素、甘草酸及甘草苷可作为该方的Q-marker。Taohe Chengqi Decoction is a classical prescription for removing heat and blood stasis,possessing anti-inflammatory,immunomodulatory,hemorheological,renal interstitial fibrosis and other pharmacological effects,which is often used to treat diseases of internal medicine,orthopedics,and obstetrics and gynecology.This article reviewed the chemical composition,pharmacological effects and clinical application of Taohe Chengqi Decoction.On this basis,Q-marker of Taohe Chengqi Decoction was predicted and analyzed according to the"five principles"of Q-marker.These results suggested that amygdalin,cinnamic acid,Cinnamaldehyde,rhein,emodin,glycyrrhizic acid and liquiritin can be used as Q-markers in Taohe Chengqi Decoction.

关 键 词：桃核承气汤 质量标志物 化学成分 药理作用 临床应用 综述 

分 类 号：R284.1[医药卫生—中药学] R285[医药卫生—中医学]