强脉冲光联合红光及他克莫司软膏治疗面部脂溢性皮炎疗效观察  

The Efficacy of Intense Pulsed Light Combined with Red Light and Tacrolimus Ointment in Treatmenting Facial Seborrheic Dermatitis

作　　者：方培炫 朱璐[1] 冯雷[1] 刘清[1] 雷水生[1] 黄美兴[1] Fang Peixuan;Zhu Lu;Feng Lei;Liu Qing;Lei Shuisheng;Huang Meixing(Department of Dermatology,Key Laboratory of Biological Targeting Diagnosis,Therapy and Rehabilitation of Guangdong Higher Education Institutes,The Fifth Affiliated Hospital of Guangzhou Medical University,Guangzhou 510700,Guangdong,China)

机构地区：[1]广州医科大学附属第五医院皮肤科广东高校生物靶向诊治与康复重点实验室,广东广州510700

出　　处：《应用激光》2023年第3期169-174,共6页Applied Laser

基　　金：广州市卫生健康科技项目(20201A010068)。

摘　　要：目的:探讨强脉冲光(IPL)和或红光联合他克莫司软膏治疗面部脂溢性皮炎(SD)的临床疗效。方法:纳入201例面部SD患者,随机分为试验组A、B、C和对照组。对照组外用他克莫司软膏,试验组C、B和A在前者基础上分别联合红光、IPL、红光和IPL治疗,疗程共8周。治疗结束后评估疗效及不良反应等。结果:IPL和或红光联合他克莫司软膏治疗后,症状体征均明显改善(P<0.05);其中试验组B对抑制皮脂腺分泌和试验组A对皮损面积、瘙痒改善更明显;各组红斑的改善幅度无明显差异(P>0.05);四组有效率比较差异具有统计学意义(P<0.05)。经联合治疗后,角质层含水量增加和经表皮失水量减少,生活质量好转,患者满意度较高。四组均无严重不良反应。结论:IPL、红光联合他克莫司软膏治疗面部SD安全有效。Objective:Evaluating the efficacy and safety of intense pulsed light(IPL)and red light combined with tacrolimus ointment in the treatment of facial seborrheic dermatitis(SD).Methods:201 patients with facial SD were randomly divided into experimental group A,B,C and control group.Control group was treated with tacrolimus ointment,experimental group C,B,and A were treated with red light,IPL,red light and IPL on the basis of the former.The course of treatment was 8 weeks.The therapeutic effect and the adverse reactions were evaluated after the treatment.Rseults:The symptoms and signs were significantly improved after treatment with IPL and red light(P0.05).Experimental group B inhibited seborrhea and experimental group A improved the skin lesion area and pruritus more obviously.There was no significant difference in the improvement degree of erythema(P0.05).There was statistically significant difference in effective rate among the four groups(P0.05).After combined treatment,cuticle moisture content,transepidermal water loss and quality of life were improved,and patient satisfaction was higher.There were no serious adverse reactions in the four groups.Conclusion:IPL and red light combined with tacrolimus ointment are safe and effective in the treatment of facial SD.

关 键 词：强脉冲光 红光 脂溢性皮炎 他克莫司软膏 

分 类 号：R758.732[医药卫生—皮肤病学与性病学] R751.05[医药卫生—临床医学]