分泌型模块化钙结合蛋白-2的功能研究进展  

Research progress on the function of secreted modular calcium binding protein 2

作　　者：杜佳敏 吴会会 李文静 李莹 苏国海 DU Jiamin;WU Huihui;LI Wenjing;LI Ying;SU Guohail(Department of Cardiology,Ji'nan Central Hospital,Cheeloo College of Medicine,Shandong University,Ji'nan 250013,China;Research Center of Translational Medicine,Central Hospital Affiliated to Shandong First Medical University,Jinan 250013,China)

机构地区：[1]山东大学齐鲁医学院,济南市中心医院心内科,济南250013 [2]山东第一医科大学附属中心医院专科转化研究中心,济南250013

出　　处：《生命的化学》2023年第3期360-366,共7页Chemistry of Life

基　　金：国家自然科学基金项目(81700217);山东省自然科学基金面上项目(ZR2021MH019,ZR2016HB57);济南市临床医学科技创新计划项目(202225025);中国博士后基金面上项目(2019M662370);山东省博士后创新项目(202003046);大数据人工智能支撑的高血压防控救治体系及个性化健康医疗服务平台建设项目(YDZX2021116)。

摘　　要：基质细胞蛋白是细胞外基质(extracellular matrix,ECM)的非结构成分,可以调节细胞外基质和细胞间的相互作用。分泌型模块化钙结合蛋白-2(secreted modular calcium binding protein-2,SMOC-2)是一种基质细胞蛋白,属于富含半胱氨酸的酸性分泌蛋白(secreted protein acidic and rich in cysteine,SPARC)家族。SMOC-2可以通过细胞外钙(extracellular calcium-binding,EC)结构域与胶原蛋白、硫酸乙酰肝素聚糖和整合素等进行结合,参与多种信号通路,从而在不同的生物过程中发挥作用。研究证实,SMOC-2能够影响细胞周期,调节生长因子的血管生成作用,并介导细胞附着和迁移,在胚胎发育、组织纤维化和钙化、炎症反应以及肿瘤的发生发展等方面都具有重要意义。但SMOC-2与疾病关联的具体机制和更多生物学功能尚需进一步研究。Matricellular proteins are non-structural components of extracellular matrix(ECM),which can regulate interactions between extracellular matrix and cells.SMOC-2 is a kind of matricellular protein,belonging to the secreted protein acidic and rich in cysteine(SPARC)family.SMOC-2 can bind to collagen,heparan sulfate proteoglycan and integrin through the extracellular calcium-binding(EC)domain and participate in a variety of signaling pathways,thus playing a role in different biological processes.Studies have confirmed that SMOC-2 involves in the regulation of cell cycle,angiogenesis mediated by growth factors and cell attachment and migration,which is of great significance in embryonic development,tissue fibrosis and calcification,inflammatory reaction,tumor occurrence and development,etc.However,the detailed mechanisms and more biological functions of SMOC-2 associated with diseases need further studies.

关 键 词：SMOC-2 基质细胞蛋白 生物学功能 疾病 

分 类 号：R341[医药卫生—基础医学]