马尔尼菲篮状菌病合并其他机会性感染的临床特征研究进展  

Advances in clinical characteristics of talaromycosis combined with other opportunistic infections

作　　者：杨振铭 黄捷 陈香梅 蒙雪 邱晔 曾文[3] 张建全 Yang Zhenming;Huang Jie;Chen Xiangmei;Meng Xue;Qiu Ye;Zeng Wen;Zhang Jianquan(Department of Respiratory and Critical Medicine,the Eighth Affiliated Hospital,Sun Yat-sen University,Shenzhen 518033,China;Department of Respiratory and Critical Care Medicine,the Fourth People′s Hospital of Nanning,Nanning 530002,China;Department of Respiratory and Critical Medicine,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China;Department of Respiratory and Critical Medicine,the First Affiliated Hospital of Guangzhou Medical University,Guangzhou 510120,China)

机构地区：[1]中山大学第八附属医院呼吸与危重症医学科,深圳518033 [2]广西南宁市第四人民医院呼吸与危重症医学科,南宁530002 [3]广西医科大学第一附属医院呼吸与危重症医学科,南宁530021 [4]广州医科大学附属第一医院呼吸与危重症医学科,广州510120

出　　处：《中华结核和呼吸杂志》2023年第5期503-506,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：广西壮族自治区科技厅重点研发计划项目(GuikeAB20238025);深圳市科技项目(JCYJ20210324115000002)。

摘　　要：马尔尼菲篮状菌病(TSM)是流行于东南亚及我国南方地区的一种机会性深部真菌病,好发于HIV阳性、抗IFN-γ自身抗体阳性等有免疫缺陷的宿主,常同时合并结核分枝杆菌、非结核分枝杆菌、细菌、真菌、病毒等机会性感染。不同免疫状态TSM合并机会性感染的临床特征和病原体谱有所差异,临床误诊漏诊及病死率高。本文对TSM合并机会性感染的临床特征进行综述,提高临床诊治水平。Talaromycosis(TSM)is an opportunistic deep mycosis prevalent in southeast Asia and southern China,affecting HIV-positive,anti-interferon-gamma autoantibody-positive and other immunodeficiency hosts.These hosts are often co-infected with mycobacterium tuberculosis,non-tuberculosis mycobacteria,bacteria,fungi,viruses and other opportunistic infections.The clinical characteristics and the pathogenic spectrum of TSM with opportunistic infections vary with different immune states.The rates of misdiagnosis,missed diagnosis and mortality are high.This review summarized the clinical characteristics of TSM with opportunistic infections in order to improve the level of clinical diagnosis and treatment.

关 键 词：深部真菌病 机会性感染 免疫缺陷 结核分枝杆菌 临床特征 病死率高 TSM 

分 类 号：R519[医药卫生—内科学]