正五聚蛋白3在肺部感染性疾病中的免疫作用及研究进展  

Immune function and research progress of pentraxin 3 in pulmonary infectious diseases

作　　者：宋梦月 顾彧 王佳美 刘璐璐 李培 苏欣 Song Mengyue;Gu Yu;Wang Jiamei;Liu Lulu;Li Pei;Su Xin(Department of Respiratory and Critical Care Medicine,Jinling Hospital,Nanjing Medical University,Nanjing 210002,China;Department of Respiratory and Critical Care Medicine,Jinling Hospital,Medical School of Nanjing University,Nanjing 210002,China;Department of Respiratory and Critical Care Medicine,Taikang Xianlin Drum Tower Hospital,Nanjing 210046,China)

机构地区：[1]南京医科大学附属金陵医院(东部战区总医院)呼吸与危重症医学科,南京210002 [2]南京大学医学院附属金陵医院(东部战区总医院)呼吸与危重症医学科,南京210002 [3]南京泰康仙林鼓楼医院呼吸与危重症医学科,南京210046

出　　处：《中华结核和呼吸杂志》2023年第5期517-520,共4页Chinese Journal of Tuberculosis and Respiratory Diseases

基　　金：国家自然科学基金(82070011);白求恩·中青年医生慢阻肺科研发展基金面上项目(BJ-RW2020004J)。

摘　　要：正五聚蛋白3属于正五聚蛋白家族成员之一,是一种急性时相蛋白,由多种类型细胞合成并储存在细胞内。在微生物入侵及发生炎症反应时,PTX3作为固有免疫的重要一环,快速释放到细胞外,通过调节补体激活,促进髓系细胞识别病原体,发挥多种免疫作用。近年研究表明,感染后外周血或组织中的PTX3浓度迅速升高,其升高水平常和疾病的严重程度密切相关。因此,PTX3作为肺部感染性疾病的诊断及预后的生物标志物,具有重要临床价值。Pentraxins3(PTX3)is an acute-phase protein of the pentraxin family that is synthetized and stored in a variety of cells.As an important mediator of innate immunity,PTX3 is rapidly released during microbial invasion and inflammatory response.It promotes the recognition of pathogens by myeloid cells through regulating complement activation.Recent studies have indicated that PTX3 concentrations in peripheral blood or tissues increase rapidly after infection,and the increased level is associated with the severity of the disease.Thus,PTX3 appears to be a vital clinical biomarker in the diagnosis and prognosis of pulmonary infectious diseases.

关 键 词：肺部感染性疾病 急性时相蛋白 固有免疫 髓系细胞 补体激活 免疫作用 微生物入侵 生物标志物 

分 类 号：R563.1[医药卫生—呼吸系统]