奶嘴形主动脉瓣支架经导管植入动物实验研究  

The replacement of the aortic valve through transcatheter implantation of a nipple-type self-expandable valved stent: an experimental study in animals

作　　者：诸治栋 于洋 王波 曹俊雄 吴丹宁 陈翔 ZHU Zhidong;YU Yang;WANG Bo;CAO Junxiong;WU Danning;CHEN Xiang(Graduate School of Zhejiang University of Traditional Chinese Medicine,Hangzhou,Zhejiang Province 310013,China)

机构地区：[1]浙江中医药大学研究生院,浙江杭州310013 [2]解放军联勤保障部队第903医院心血管内科

出　　处：《介入放射学杂志》2023年第4期350-353,共4页Journal of Interventional Radiology

基　　金：浙江省医药卫生科技计划项目(2018261479);杭州市科技发展计划(20170533B97)。

摘　　要：目的探讨经导管植入奶嘴形带瓣膜主动脉瓣支架置换动物主动脉瓣的可行性。方法选择健康实验山羊3只,全麻下分离腹主动脉,经腹主动脉穿刺送入加硬导丝至左心室建立轨道。透视下沿加硬导丝将预载有奶嘴形支架的20 F输送鞘管的头端送至左心室内,缓慢后撤外鞘,定位准确后释放整个支架,手术后即刻观察实验效果。结果3只实验羊经导管主动脉瓣植入术均获得成功,术后即刻DSA及解剖学评价表明人工主动脉瓣膜植入位置理想,代替原瓣膜工作。结论新型奶嘴形主动脉瓣支架经导管植入可行,操作简单,效果理想。Objective To discuss the feasibility of transcatheter implantation of a nipple-type self-expandable valved stent to replace the aortic valve. Methods Three healthy experimental goats were selected for this study. Under general anesthesia, the abdominal aorta was isolated, and a hardened guidewire was inserted into the left ventricle through abdominal aortic puncture to establish the working path. Under fluoroscopy guidance,the heading end of a 20 F transport sheath carrying a pre-loaded nipple-type self-expandable valved stent was inserted into the left ventricle along the hardened guidewire, then, the external sheath was slowly withdrawn,the whole stent was released after accurately positioning, and the experimental effect was observed immediately after the procedure. Results Successful transcatheter implantation of aortic valve was accomplished in all the three experimental goats. The immediate postoperative DSA and anatomical evaluation showed that the artificial aortic valve was implanted in an ideal position, and it was able to replace the work of the original valve. Conclusion Transcatheter implantation of a nipple-type self-expandable valved stent to replace the original aortic valve is clinically feasible. Its operation is simple, and the effect is ideal.

关 键 词：瓣膜支架 主动脉瓣膜置换 支架移位 

分 类 号：R542.5[医药卫生—心血管疾病]