特发性肺纤维化患者中阻塞性睡眠呼吸暂停低通气综合征的流行病学研究——meta分析  

Epidemiologic study on obstructive sleep apnea and hypopnea syndrome in idiopathic pulmonary fibrosis patients:A meta-analysis

作　　者：徐依婷 钟秀君[2] 谢素馨 汤杰[1] Xu Yiting;Zhong Xiujun;Xie Suxin;Tang Jie(Department of Respiratory Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China;Department of Infection Medicine,Yueyang Hospital of Integrated Traditional Chinese and Western Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200437,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院呼吸内科,上海200437 [2]上海中医药大学附属岳阳中西医结合医院感染科,上海200437

出　　处：《国际呼吸杂志》2023年第4期410-418,共9页International Journal of Respiration

基　　金：上海人才发展资金项目(RY410.14.02);虹口区"国医强优"三年行动计划名中医工作室项目(HKGYQYXM-2022-39);岳阳医院院级课题,中医专科项目管理平台建设(YW211.03.05.01)。

摘　　要：目的研究特发性肺纤维化(IPF)患者中阻塞性睡眠呼吸暂停低通气综合征(OSAHS)的流行情况及严重程度。方法依据PRISMA指南系统性检索PubMed、Embase、知网、SinoMed等数据库,搜寻并筛选从相关数据库最早发表相关文献的时间至2022年2月的全部文献,采用Stata 12.0进行meta分析。结果纳入14篇文献,共计513例IPF患者。IPF患者中OSAHS的总患病率为81%(95%CI:75%~87%),异质性I2=58%;其中轻度OSAHS总患病率为20%(95%CI:13%~26%),异质性I2=71%;中重度OSAHS总患病率为55%(42%~68%),异质性I2=89%。结论IPF中OSAHS的患病率较高,值得引起临床重视。而对OSAHS的治疗能够改善IPF患者生活质量,因此有必要针对IPF患者提早进行OSAHS患病情况的筛查,并改善患者睡眠时的通气状态,结合IPF的基础性治疗(抗纤维化药物治疗及肺康复训练)、中医药治疗或许能延长IPF患者的生存期,关于这点有待更多的研究进一步证实。Objective To study the prevalence and severity of obstructive sleep apnea and hypopnea syndrome(OSAHS)in idiopathic pulmonary fibrosis(IPF)patients.Methods PubMed,Embase,CNKI,SinoMed and similar databases were systematically searched based on the Preferred Reporting Items for Systematic reviews and meta-analyses(PRISMA)statement,all relevant literatures from the earliest publication date to February 2022 were found and screened.Stata software version 12.0 was used for the meta analysis.Results Totally 14 articles representing 513 IPF patients were included.The overall prevalence rate of OSAHS in IPF patients was 81%(95%CI:75%-87%)with a heterogeneity of I2=58%.The overall prevalence rate of mild OSAHS was 20%(95%CI:13%-26%)with a heterogeneity I2=71%.The overall prevalence rate of moderate or severe OSAHS was 55%(42%-68%)with a heterogeneity of I2=89%.Conclusions The high prevalence rate of OSAHS in IPF should be emphasized in clinical practice.The treatment of OSAHS can improve the quality-of-life of IPF patients,so it is necessary to early screen OSAHS in IPF patients for improving disordered sleep ventilation.Both the treatment of OSAHS combined with basic treatment of IPF(anti-fibrosis drug therapy and pulmonary rehabilitation training)and traditional Chinese medicine therapy may prolong the survival period of IPF patients,and more researches are needed to confirm the conclusion.

关 键 词：特发性肺纤维化 阻塞性睡眠呼吸暂停低通气综合征 META分析 

分 类 号：R766[医药卫生—耳鼻咽喉科] R181.3[医药卫生—临床医学] R563