Photo-triggered Intramolecular Radical Tandem Regioselective Alkylation/Cyclization of 1,6-Dienes with Redox-Active Esters Enabled by an EDA Complex  

作　　者：Bin Sun Lan Ling Xiaohui Zhuang Lulu Yang Jieli Yin Can Jin 

机构地区：[1]Collaborative Innovation Center of Yangtze River Delta Region Green Pharmaceuticals,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China [2]College of Pharmaceutical Sciences,Zhejiang University of Technology,Hangzhou,Zhejiang 310014,China

出　　处：《Chinese Journal of Chemistry》2023年第1期37-42,共6页中国化学（英文版）

基　　金：supported by the National Natural Science Foundation of China(22078299 and 22108250);the Natural Science Foundation,of Zhejiang Province(LY21B060005 and LQ20B06007);Research project of Zhejiang Provincial Department of Education(Y20840109)。

摘　　要：A photocatalyst-and metal-free radical tandem alkylation/cyclization between 1,6-dienes and redox-active esters has been devel-oped,affording a series of N-aryl pyrrolidine-2-ones in moderate to good yields.The transformation is driven by the formation of an electron-donor-acceptor(EDA)complex and a subsequent single electron transfer(SET)process.This photocatalyst-free protocol features excellent regioselectivity,mild conditions and broad substrate scope,providing a facile access to 3-alkyl-3,4-dimethyl-1-phe-nylpyrrolidin-2-one.

关 键 词：ALKYLATION CYCLIZATION EDA COMPLEX PYRROLIDONE Photocatalysis 

分 类 号：O62[理学—有机化学]