不同免疫功能状态格特型隐球菌性脑膜炎的研究进展  

Research progress of Cryptococcus gattii meningitis with different immune status

作　　者：戴恺 苏芷惠 覃榜娥 彭福华[1] 江滢[1] Dai Kai;Su Zhihui;Qin Bang′e;Peng Fuhua;Jiang Ying(Department of Neurology,the Third Affiliated Hospital of Sun Yat-Sen University,Guangzhou 510630,China)

机构地区：[1]中山大学附属第三医院神经内科,广州510630

出　　处：《中华神经科杂志》2023年第5期566-571,共6页Chinese Journal of Neurology

基　　金：国家自然科学基金面上项目(81671182);广东省自然科学基金面上项目(2016A030313228)。

摘　　要：格特型隐球菌是隐球菌的一种主要类型,其通过孢子或小酵母细胞等感染性颗粒的吸入而感染肺和脑。格特型隐球菌感染疾病的发展可能由宿主的性别、免疫及遗传等因素决定,其中免疫因素在宿主患病中至关重要。格特型隐球菌主要感染免疫正常人群,免疫抑制人群的感染较为少见。两种人群的格特型隐球菌性脑膜炎的相关机制、病原菌的分子类型、临床特点、治疗和预后均有不同。文中对不同免疫功能状态格特型隐球菌性脑膜炎的主要区别进行综述。Cryptococcus gattii is a kind of Cryptococcus that infects the lungs and central nervous system through the inhalation of infectious particles such as spores or Cryptococcus yeast cells.The development of clinical disease of Cryptococcus gattii may be determined by the sex,immunity and genetics of the host factors,in which immune system factors play an important role in host injury.Their defects will have serious clinical consequences.Cryptococcus gattii mainly infects the population with normal immune,and the infection of immunosuppressed population is rare.The infection mechanism,molecular types,clinical characteristics,treatment and prognosis of Cryptococcus gattii meningitis were different between the two populations.This article reviews the main differences in different immune status with Cryptococcus gattii meningitis.

关 键 词：格特型隐球菌 隐球菌性脑膜炎 免疫功能 基因型 

分 类 号：R519.4[医药卫生—内科学]