Determiners of cell fates: the tricarboxylic acid cycle versusthe citrate-malate shuttle  

作　　者：Dong Guo Haiyan He Ying Meng Shudi Luo Zhimin Lu 

机构地区：[1]Zhejiang Provincial Key Laboratory of Pancreatic Disease,The First Affliated Hospital,and Institute of Translational Medicine,Zhejiang University School of Medicine,Zhejiang University,Hangzhou 310029,China [2]Cancer Center,Zhejiang University,Hangzhou 310029,China

出　　处：《Protein & Cell》2023年第3期162-164,共3页蛋白质与细胞（英文版）

基　　金：supported by grants from the Ministry of Science and Technology of the People's Republic of China(2020YFA0803300,Z.L.);the National Natural Science Foundation of China(82188102,82030074,Z.L.;81902423,D.G.);ZhejiangNatural ScienceFoundation Key Project(LD21H160003,Z.L.);the Leading Innovative and Entrepreneur Team Introduction Program of Zhejiang(2019R01001,Z.L.).Z.L.is the Kuancheng Wang Distinguished Chair.

摘　　要：The tricarboxylic acid(TCA)cycle identified in 1937 by Hans Adolf Krebs and William Arthur Johnson(also known as the Krebs cycle or citric acid cycle)is a central route for oxidative metabolism to generate cellular energy and intermediates for the biosynthesis of amino acids,lipids,and nucleic acids(Krebs and Johnson 1937).The TCA cycle connects carbohydrate,fat,and protein metabolism and converts these nutrient catabolism-derived acetyl-CoA into carbon dioxide and water,with the production of reduced NAD+(NADH),reduced flavin adenine dinucleotide(FADH2),and guanosine triphosphate(GTP).The generated NADH and FADH2 are,in turn,used by the oxidative phosphorylation pathway to generate energy-rich adenosine triphosphate(ATP)(Chakrabarty and Chandel 2021).

关 键 词：CYCLE OXIDATIVE carboxylic 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学]