GPU-accelerated three-dimensional reconstruction method of the Compton camera and its application in radionuclide imaging  

作　　者：Ren-Yao Wu Chang-Ran Geng Feng Tian Zhi-Yang Yao Chun-Hui Gong Hao-Nan Han Jian-Feng Xu Yong-Shun Xiao Xiao-Bin Tang 

机构地区：[1]Department of Nuclear Science and Technology,Nanjing University of Aeronautics and Astronautics,Nanjing 210016,China [2]Department of Engineering Physics,Tsinghua University,Beijing 100084,China [3]School of Environmental and Biological Engineering,Nanjing University of Science and Technology,Nanjing 210094,China [4]JYAMS PET Research and Development Limited,Nanjing 211100,China

出　　处：《Nuclear Science and Techniques》2023年第4期54-68,共15页核技术（英文）

基　　金：supported by the National Natural Science Foundation of China (No. 12220101005);Natural Science Foundation of Jiangsu Province (No. BK20220132);Primary Research and Development Plan of Jiangsu Province (No. BE2019002-3);Fundamental Research Funds for Central Universities (No. NG2022004);the Foundation of the Graduate Innovation Center in NUAA (No. xcxjh20210613)。

摘　　要：A novel and fast three-dimensional reconstruction method for a Compton camera and its performance in radionuclide imaging is proposed and analyzed in this study. The conical surface sampling back-projection method with scattering angle correction(CSS-BP-SC) can quickly perform the back-projection process of the Compton cone and can be used to precompute the list-mode maximum likelihood expectation maximization(LM-MLEM). A dedicated parallel architecture was designed for the graphics processing unit acceleration of the back-projection and iteration stage of the CSS-BP-SC-based LM-MLEM. The imaging results of the two-point source Monte Carlo(MC) simulation demonstrate that by analyzing the full width at half maximum along the three coordinate axes, the CSS-BP-SC-based LM-MLEM can obtain imaging results comparable to those of the traditional reconstruction algorithm, that is, the simple back-projection-based LM-MLEM. The imaging results of the mouse phantom MC simulation and experiment demonstrate that the reconstruction results obtained by the proposed method sufficiently coincide with the set radioactivity distribution, and the speed increased by more than 664 times compared to the traditional reconstruction algorithm in the mouse phantom experiment. The proposed method will further advance the imaging applications of Compton cameras.

关 键 词：Compton camera Three-dimensional reconstruction Radionuclide imaging GPU 

分 类 号：R81[医药卫生—放射医学] TP391.41[医药卫生—临床医学]