纤维自动量化在阿尔茨海默病患者面部情绪识别研究中的应用  

Application of automated fiber quantification in research of facial emotion recognition in patients with Alzheimer's disease

作　　者：贾巴见明 罗琳[2] 原小军[2] 陈强[2] JIABA Jianming;LUO Lin;YUAN Xiaojun;CHEN Qiang(Baotou Medical College,Inner Mongolia University of Science&Technology,Baotou 014040,China;Department of Medical Imaging,the First Affiliated Hospital of Baotou Medical College,Inner Mongolia University of Science&Technology,Baotou 014010,China)

机构地区：[1]内蒙古科技大学包头医学院,包头014040 [2]内蒙古科技大学包头医学院第一附属医院医学影像科,包头014010

出　　处：《磁共振成像》2023年第5期66-71,共6页Chinese Journal of Magnetic Resonance Imaging

基　　金：内蒙古自治区高等学校科学研究项目(编号:NJZY23021)。

摘　　要：目的 探讨基于扩散张量成像的纤维自动量化(automated fiber quantification, AFQ)在阿尔茨海默病(Alzheimer's disease, AD)患者面部情绪识别(facial emotion recognition, FER)神经基础研究中的应用。材料与方法 对17例AD患者(AD组)和2l例正常对照(normal control, NC)者(NC组)进行FER测验和3.0 T MR扫描。采用AFQ将下额枕束、钩状束、下纵束等纤维束分成100个节段并提取主要纤维束各向异性分数(fractional anisotropy, FA)和平均扩散系数(mean diffusivity, MD)。采用独立样本t检验比较两组上述纤维束FA和MD值差异。以性别、年龄、简易精神状态量表评分作为协变量,将进行受损纤维FA、MD值与FER评分的偏相关性分析。结果 AFQ分析显示,AD组左侧下额枕束中段(节段44~46)和左侧钩状束下段(节段89~99)FA值均低于NC组(t值分别为-6.319和-7.825,P均<0.05),且均与FER消极评分呈显著正相关(r值分别为0.386和0.384,P均<0.05);AD组左侧下纵束中段(节段45~64)MD值高于NC组(t=3.059,P<0.05),与消极FER评分呈显著负相关(r=-0.485,P=0.003)。结论 采用AFQ能更精确地发现纤维束受损节段,左侧下纵束、下额枕束中段和左侧钩状束下段受损可能是AD患者消极FER障碍的潜在神经基础。Objective:To explore the application of automated fiber quantification(AFQ)based on diffusion tensor imaging(DTI)in the neurological basic research of facial emotion recognition(FER)disorder in patients with Alzheimer's disease(AD).Materials and Methods:FER test and 3.0T MR Scan were performed in 17 AD patients(AD group)and 2l normal control patients(NC group).Fibers like inferior fronto-occipital fasciculus(IFOF),uncinate fasciculus(UF)and inferior longitudinal fasciculus(ILF)were divided into 100 nodes using AFQ,and then extracted the fractional anisotropy(FA)and mean diffusivity(MD)values of main fibers.The differences in FA and MD values between the two groups of fibers mentioned above were compared using two-tailed t-tests.Age,gender and mini-mental state examination were regarded as covariates,partial correlation analysis was conducted between DTI parameters of damaged fibers and FER scores.Results:AFQ analysis showed that the FA values of the middle part(nodes 44-46)of left IFOF and the inferior segment(nodes 89-99)of left UF in AD group were significantly lower than that in NC group(t values were-6.319 and-7.825,both P<0.05),and were positively correlated with the negative FER scores(r values were 0.386 and 0.384,both P<0.05).The MD value of the middle part(nodes 45-64)of left inferior ILF in AD group was significantly higher than that in NC group(t=3.059,P<0.05),and was negatively correlated with the negative FER scores(r=-0.485,P=0.003).Conclusions:AFQ can be used to detect the damaged segment of white matter fiber accurately.The impaired of the middle segment of left ILF,left IFOF,and the inferior part of left UF may be the potential neural basis of negative FER disorder in AD patients.

关 键 词：阿尔茨海默病 面部情绪识别 扩散张量成像 纤维自动量化 磁共振成像 

分 类 号：R445.2[医药卫生—影像医学与核医学] R745.1[医药卫生—诊断学]