动脉自旋标记成像诊断干燥综合征早期腮腺损伤的临床价值  

Clinical value of arterial spin labeling imaging in the diagnosis of early parotid gland injury in Sjögren's syndrome

作　　者：张高正博 田曼婷 丁长伟[1] 王百军 ZHANG Gaozhengbo;TIAN Manting;DING Changwei;WANG Baijun(Department of Radiology,Shengjing Hospital of China Medical University,Shenyang 110004,China;Philips(China)Investment Co.,Ltd,Shanghai 200040,China)

机构地区：[1]中国医科大学附属盛京医院放射科,沈阳110004 [2]飞利浦(中国)投资有限公司,上海200040

出　　处：《磁共振成像》2023年第5期92-95,131,共5页Chinese Journal of Magnetic Resonance Imaging

基　　金：辽宁省自然科学基金(编号:20170541045)。

摘　　要：目的 探讨动脉自旋标记(arterial spin labeling, ASL)技术对评估干燥综合征(Sjogren's syndrome, SS)的早期腮腺损伤的价值。材料与方法 纳入首次确诊未经治疗且腮腺内无脂肪沉积的早期SS患者30例,与健康志愿者30例对照,行腮腺ASL成像,测量腮腺血流量,比较早期SS患者与健康志愿者腮腺血流量的差异,绘制受试者工作特征(receiver operating characteristic, ROC)曲线分析腮腺血流量对早期SS患者的诊断效能。结果 早期SS患者及健康志愿者左右两侧腮腺的BF值差异无统计学意义(P>0.05)。早期SS患者的腮腺血流量显著高于健康志愿者[(22.54±1.98) vs.(20.46±2.45) mL/min/100g,(P<0.01)]。ROC曲线评价腮腺BF值对早期SS患者有良好的诊断效能,最佳截断值为20.79 mL/min/100g,曲线下面积为0.808,敏感度为80%,特异度为75%。结论 ASL技术能评价早期SS患者腮腺的血流量变化,有潜力成为早期SS筛查的技术。Objective:To investigate the value of arterial spin labeling(ASL)technology in the evaluation of early parotid gland damage in Sjögren's syndrome(SS).Materials and Methods:Thirty patients with early SS who were diagnosed for the first time without treatment and no fat deposits in the parotid gland were collected,and 30 healthy volunteers were controlled.Parotid gland ASL imaging was performed,and parotid blood flow was measured.The difference between parotid gland blood flow between early SS patients and healthy volunteers was compared,and the receiver operating characteristic(ROC)curve was plotted to analyze the diagnostic efficacy of parotid blood flow on early SS patients.Results:There was no statistically significant difference in BF values between the left and right parotid glands of early SS patients and healthy volunteers(P>0.05).The parotid gland blood flow of early SS patients was significantly higher than that of healthy volunteers[(22.54±1.98)vs.(20.46±2.45)mL/min/100 g,(P<0.01)].The ROC curve evaluation of parotid gland BF value has good diagnostic efficacy for early SS patients.The optimal cutoff value is 20.79 mL/min/100 g,the area under the curve is 0.808,the sensitivity is 80%,and the specificity is 75%.Conclusions:ASL technology can evaluate the changes of blood flow in parotid gland in patients with early SS,and has the potential to become a technique for early SS screening.

关 键 词：干燥综合征 腮腺 磁共振成像 动脉自旋标记 微循环灌注 临床价值 

分 类 号：R445.2[医药卫生—影像医学与核医学] R442.8[医药卫生—诊断学]