丙种球蛋白联合布地奈德治疗新生儿肺炎的效果分析  

Effect analysis of gamma globulin combined with budesonide in the treatment of neonatal pneumonia

作　　者：韩思 HAN Si(Pediatrics Ward I,the First People′s Hospital of Pingdingshan,Pingdingshan 467000,China)

机构地区：[1]平顶山市第一人民医院儿科一病区,河南平顶山467000

出　　处：《华夏医学》2023年第1期56-60,共5页Acta Medicinae Sinica

摘　　要：目的:分析丙种球蛋白联合布地奈德治疗新生儿肺炎的临床效果。方法:选取146例新生儿肺炎患者,将其分为常规组和联合组,每组73例。常规组采用布地奈德治疗,联合组在常规组基础上联合丙种球蛋白治疗,比较两组治疗效果、住院时间、临床症状消失时间、肺功能、炎性因子、免疫功能及不良反应发生情况。结果:治疗后,联合组总有效率95.89%高于常规组84.93%,肺部啰音消失时间、呼吸急促消失时间、口周发绀消失时间及住院时间均短于常规组,差异均有统计学意义(P<0.05);治疗后,联合组FEV_1、FVC、PEF均高于常规组(P<0.05);治疗后,联合组HMGB1、MMP-9、sTREM-1、hs-CRP水平均低于常规组(P<0.05);治疗后,CD3^(+)细胞、CD4^(+)细胞、IgG、IgM、IgA水平均高于常规组(P<0.05);两组不良反应发生比较,无统计学差异(P>0.05)。结论:丙种球蛋白联合布地奈德可提高新生儿肺炎免疫功能,改善肺功能。Objective:To analyze the clinical efficacy of gamma globulin combined with budesonide in the treatment of neonatal pneumonia.Methods:146 cases of neonates with pneumonia were randomized into the conventional group and combination group,each with 73 cases.The conventional group adopted treatment with budesonide,while the combination group were treated with gamma globulin plus budesonide.The treatment effect hospital length of stay,time for the dinical sympton reduction,pulmonary function,inflammatory factors,immune function and incidence of adverse reactions were compared between both groups.Results:After treatment,the total effective rate of the combination group was 95.89%,higher than 84.93%of the conventional group,and the disappearance time of lung rales,shortness of breath,perioral cyanosis and hospital stay were shorter than that of the conventional group,the differences were statistically significant(P<0.05);FEV1,FVC and PEF levels were all higher in the combination group than in the conventional group(P<0.05);(high mobility group box 1,HMGB1),(matrix metalloproteinase-9,MMP-9),soluble triggering receptor expressed on myeloid cell-1(sTREM-1),high-sensitivity C-reactive protein(hs-CRP)levels were lower in the combined group than in the conventional group(P<0.05),while CD3+cells,CD4+cells,IgG,IgM and IgA levels were all higher in the combination group than in the conventional group(P<0.05).There were no statistical differences of the occurrence of adverse reactions between both groups(P>0.05).Conclusion:Gamma globulin combined with budesonide are able to improve the neonatal immune function and pulmonary function in neonates.

关 键 词：丙种球蛋白 布地奈德 新生儿肺炎 高迁移率族蛋白1 金属基质蛋白酶-9 

分 类 号：R722.13[医药卫生—儿科]