血清cMyBP-C、H-FABP、CK-MB及BNP联合检测在早期急性心肌梗死患者诊断中的应用研究  

Application of Combined Detection of Serum Cmybp-c,H-FABP,CK-MB and BNP in the Diagnosis of Patients with Early Acute Myocardial Infarction

作　　者：苗成林 MIAO Chenglin(Department of Laboratory,Jiyuan People's Hospital,Jiyuan 454650 China)

机构地区：[1]济源市人民医院检验科,河南济源454650

出　　处：《内蒙古医学杂志》2023年第2期145-148,共4页Inner Mongolia Medical Journal

摘　　要：目的探讨血清心脏肌球蛋白结合蛋白C(cMyBP-C)、心脏型脂肪酸结合蛋白(H-FABP)、肌酸激酶同工酶(CK-MB)、脑钠肽(BNP)联合检测在早期急性心肌梗死(AMI)患者诊断中的应用价值。方法选取2020年1月至2022年1月于本院收治的65例AMI患者作为观察组,同期非AMI患者65例作为对照组。所有患者均采血检测cMyBP-C、H-FABP、CK-MB及BNP水平,比较两组及不同Killip分级AMI患者血清学指标;绘制ROC曲线分析cMyBP-C、H-FABP、CK-MB、BNP及联合检测诊断早期AMI的临床价值。结果观察组cMyBP-C、H-FABP、CK-MB及BNP水平高于对照组,差异有统计学意义(P<0.05);65例AMI患者,其中Killip分级Ⅰ级29例,Ⅱ级24例,Ⅲ级12例;Ⅲ级患者cMyBP-C、H-FABP、CK-MB及BNP水平高于Ⅱ级、Ⅰ级患者,差异有统计学意义(P<0.05);绘制ROC曲线显示,cMyBP-C、H-FABP、CK-MB、BNP及联合检测诊断AMI的曲线下面积AUC分别为0.778、0.757、0.753、0.729、0.920,联合检测诊断价值最高。结论血清cMyBP-C、H-FABP、CK-MB、BNP在早期AMI诊断中具有一定价值,联合检测可进一步提高诊断灵敏度和特异度,并能够在一定程度上反映AMI的严重程度。Objective To explore the value of combined detection of serum cardiac myosin binding protein C(cmybp-c),heart fatty acid binding protein(H-FABP),creatine kinase isoenzyme(CK-MB)and brain natriuretic peptide(BNP)in the diagnosis of patients with early acute myocardial infarction(AMI).Methods A total of 65 patients with AMI treated in our hospital from January 2020 to January 2022 were taken as the observation group,and 65 non AMI patients in the same period were taken as the control group.Blood samples were taken from all patients to detect the levels of cmybp-c,H-FABP,CK-MB and BNP,and the serological indexes of the two groups and AMI patients with different Killip grades were compared;Draw ROC curve to analyze the clinical value of cmybp-c,H-FABP,CK-MB,BNP and combined detection in the diagnosis of early AMI.Results The levels of cmybp-c,H-FABP,CK-MB and BNP in the observation group were significantly higher than those in the control group(P<0.05);65 patients with AMI,including 29 patients with Killip grade I,24 patients with grade II and 12 patients with grade III;The levels of cmybp-c,H-FABP,CK-MB and BNP in grade III patients were significantly higher than those in grade II and grade I patients(P<0.05);The ROC curve showed that the area under the curve(AUC)of cmybp-c,H-FABP,CK-MB,BNP and combined detection for AMI diagnosis were 0.778,0.757,0.753,0.729 and 0.920 respectively,and the value of combined detection and diagnosis was the highest.Conclusion Serum cmybp-c,H-FABP,CK-MB and BNP have certain value in the diagnosis of early AMI.Combined detection can further improve the diagnostic sensitivity and specificity,and can reflect the severity of AMI to a certain extent.

关 键 词：急性心肌梗死 心脏肌球蛋白结合蛋白C 心脏型脂肪酸结合蛋白 肌酸激酶同工酶 

分 类 号：R542.2[医药卫生—心血管疾病]