中药调控核转录因子κB信号通路减轻皮瓣缺血再灌注损伤  

Traditional Chinese medicine regulates nuclear factor-kappa B signaling pathway against ischemia-reperfusion injury of skin flaps

作　　者：马岁录 何志军[2] 刘涛 李金鹏[2] 李岩[2] 何波 魏晓涛 王威威 Ma Suilu;He Zhijun;Liu Tao;Li Jinpeng;Li Yan;He Bo;Wei Xiaotao;Wang Weiwei(Clinical College of Traditional Chinese Medicine,Gansu University of Chinese Medicine,Lanzhou 730030,Gansu Province,China;Department of Foot and Ankle Orthopedics,Gansu Hospital of Traditional Chinese Medicine,Lanzhou 730050,Gansu Province,China)

机构地区：[1]甘肃中医药大学中医临床学院,甘肃省兰州市730030 [2]甘肃省中医院足踝骨科,甘肃省兰州市730050

出　　处：《中国组织工程研究》2023年第35期5721-5726,共6页Chinese Journal of Tissue Engineering Research

基　　金：国家自然科学基金项目(81660802),项目负责人:何志军;甘肃省中医药管理局重点课题(GZKZ-2020-2),项目负责人:何志军;甘肃省重点研发计划项目(21YF5FA021),项目负责人:何志军;甘肃省青年科技基金计划项目(21JR11RA211),项目负责人:刘涛;甘肃省人才创新创业专项(2019-RC-63),项目负责人:何志军。

摘　　要：背景:近年来,研究发现核转录因子κB信号通路通过调控下游细胞因子加重了皮瓣缺血再灌注损伤,而中药可抑制核转录因子κB的活化减轻皮瓣缺血再灌注损伤。目的:综述中药、中药有效成分以及中药复方调控核转录因子κB信号通路抗皮瓣缺血再灌注损伤的研究进展。方法:由第一作者分别以“中药,NF-κB,皮瓣,血管内皮细胞”与“Traditional Chinese Medicine(TCM),NF-κB,Skin flaps,vascular endothelial cell(VEC)”为中英文检索词,检索2012年1月至2022年10月发表在中国知网与PubMed数据库的相关文献,经筛选后最终归纳45篇进行综述。结果与结论:①激活的核转录因子κB信号通路通过转录多种细胞因子,促进组织细胞内炎性因子、黏附分子以抗纤溶促凝物质的释放,加重了缺血再灌注损伤皮瓣组织与血管内皮细胞的炎性级联反应、白细胞黏附以及微小血栓形成,引起皮瓣坏死。②中药、中药复方以及中药有效成分(黄酮类、萜类、皂苷类和酚类等)通过抑制核转录因子κB信号通路的激活,减轻缺血再灌注损伤皮瓣与血管内皮细胞的炎性级联反应、白细胞黏附以及血栓形成,发挥抗皮瓣缺血再灌注损伤的作用。③通过研究中药调控核转录因子κB信号通路在抗皮瓣缺血再灌注损伤中的作用机制,为皮瓣缺血再灌注损伤的药物研发提供新的思路,并为临床上中药防治皮瓣缺血再灌注损伤、加快皮瓣愈合提供参考与理论依据。BACKGROUND:In recent years,it has been found that nuclear factor-κB signaling pathway aggravates ischemia-reperfusion injury of skin flaps by regulating downstream cytokines,and traditional Chinese medicine can inhibit the activation of nuclear factor-κB,thereby reducing ischemia-reperfusion injury of skin flaps.OBJECTIVE:To review the research progress in the regulation of nuclear factor-κB signaling pathway by Chinese medicine,its active ingredients and Chinese medicine compound against skin flap ischemia-reperfusion injury.METHODS:The first author searched for the relevant literatures published in CNKI and PubMed databases from January 2012 to October 2022 using the keywords of“Traditional Chinese Medicine(TCM),NF-κB,Skin flaps,vascular endothelial cell(VEC)”in Chinese and English,respectively.After screening,45 articles were finally summarized for review.RESULTS AND CONCLUSION:Activated nuclear factor-κB signaling pathway can promote the release of inflammatory factors and adhesion molecules in tissue cells to anti-fibrinolytic and coagulant substances through the transcription of a variety of cytokines,and aggravate the inflammatory cascade reaction between ischemia-reperfusion-damaged flap tissue and vascular endothelial cells,leukocyte adhesion and microthrombus formation,leading to flap necrosis.Traditional Chinese medicine,its compounds and effective components(flavonoids,terpenoids,saponins,phenols,etc.)inhibit the activation of nuclear factor-κB signaling pathway,alleviate the inflammatory cascade reaction between the ischemia-reperfusion-damaged flap and vascular endothelial cells,leukocyte adhesion and thrombosis,and thereby inhibit ischemia-reperfusion injury of skin flaps.Research on the mechanism of nuclear factor-κB signaling pathway regulated by traditional Chinese medicine against ischemia-reperfusion injury of skin flaps provides a new idea for the drug research and development of skin flap ischemia-reperfusion injury,and provides reference and theoretical basis for the clinical pre

关 键 词：皮瓣 缺血再灌注 血管内皮细胞 核转录因子ΚB NF-κB 信号通路 炎性因子 黏附分子 中药 

分 类 号：R453[医药卫生—治疗学] R363[医药卫生—临床医学] R364