(叔丁氧羰基)-L-天冬酰胺的合成研究  

Study on the Synthesis of(Tert-Butoxycarbonyl)-L-Asparagine

作　　者：王金榕 张凤华[1] 李飞[1] 于芳[1] Wang Jinrong;Zhang Fenghua;Li Fei;Yu Fang(Petrochemical College,Liaoning Petrochemical University,Liaoning,113001)

机构地区：[1]石油化工学院辽宁石油化工大学,辽宁113001

出　　处：《当代化工研究》2023年第9期160-162,共3页Modern Chemical Research

摘　　要：研究了(叔丁氧羰基)-L-天冬酰胺的合成,并对该工艺条件进行了方法学研究。L-天冬酰胺、氢氧化钠和二碳酸二叔丁酯溶于水和1,4-二氧六环中,在20℃下反应12h。该工艺方法得到84%的收率,且反应条件简单温和,工艺设备成本廉价,实现了操作简单、经济实惠和绿色环保的目的。The synthesis of(tert-Butoxycarbonyl)-L-asparagine was studied,and the process conditions were methodologically studied.L-asparagine,sodium hydroxide and di-tert-butyl dicarbonate were dissolved in water and 1,4-dioxane,and reacted at 20℃for 12 hours to obtain a yield of 84%.This process method has the advantages of simple and mild reaction conditions and low cost of process equipment.Therefore,the process method achieves the purpose of simple operation,economic and green environmental protection.

关 键 词：L-天冬酰胺 二碳酸二叔丁酯 N-Boc-天冬酰胺 

分 类 号：TQ464[化学工程—制药化工]