骨源性外泌体microRNAs与骨质疏松症相关研究进展  

Progress in the research of the correlation between osteogenic exosomal microRNAs and osteoporosis

作　　者：谢兴文 闫文 顾玉彪[3] 李鼎鹏 于文霞 马成 李文广 高亚雄 XIE Xingwen;YAN Wen;GU Yubiao;LI Dingpeng;YU Wenxia;MA Cheng;LI Wenguang;GAO Yaxiong(The Affiliated Hospital of Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Gansu University of Traditional Chinese Medicine,Lanzhou 730000;Gansu Provincial Hospital of Traditional Chinese Medicine,Lanzhou 730050;The Second People’s Hospital of Gansu Province,Lanzhou 730030,China)

机构地区：[1]甘肃中医药大学附属医院,甘肃兰州730000 [2]甘肃中医药大学,甘肃兰州730000 [3]甘肃省中医院,甘肃兰州730050 [4]甘肃省第二人民医院,甘肃兰州730030

出　　处：《中国骨质疏松杂志》2023年第5期687-690,723,共5页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金(82160911);甘肃省拔尖领军人才项目;甘肃省科技计划资助(20JR5RA129);兰州市人才创新创业项目(2021-RC-131);甘肃省中医药研究中心开放课题(zyzx-2020-32);中央高校基本科研业务费项目(31920210041);甘肃省青年科技基金计划(20JR5RA129);敦煌医学与转化教育部重点实验室开放课题(DHYX19-05)。

摘　　要：骨质疏松症作为老年疾病中的一种代谢性疾病,对它的研究一直被认为是重点和难点,因此如何延缓骨质疏松症的进展成为最主要的问题。骨源性外泌体microRNAs作为骨科疾病的关键调节因子,其表达的变化对延缓骨质疏松症的进展具有调节作用。microRNAs通过调节相关因子的表达可延缓骨质疏松症的发生及进展。该文就骨源性外泌体microRNAs与骨质疏松症的相关性进行综述,以期为骨源性外泌体microRNAs在治疗骨质疏松症方面提供一些新的治疗思路。Osteoporosis as a metabolic disease among the diseases of the elderly has always been regarded as a key and difficult point to study.How to delay the progression of osteoporosis has become the most important issue.MicroRNAs are key regulators of orthopedic diseases.The changes in their expression have a regulatory effect on delaying the progression of osteoporosis.Bone-derived exosomal microRNAs may delay the occurrence and progression of osteoporosis by regulating the expression of related factors.This article reviews the correlation between bone-derived exosomal microRNAs and osteoporosis,in order to provide some new therapeutic ideas for bone-derived exosomal microRNAs in the treatment of osteoporosis.

关 键 词：骨源性外泌体 MICRORNAS 骨质疏松 成骨细胞 破骨细胞 

分 类 号：R274.9[医药卫生—中西医结合] R681[医药卫生—中医骨伤科学]