H型血管在骨发育及骨疾病中作用研究进展  

Research progress on H-Type blood vessel in bone development and bone diseases

作　　者：刘晓南 余斌[1] LIU Xiaonan;YU Bin(Department of Orthopaedics and Traumatology,Nanfang Hospital,Southern Medical University,Guangzhou 510515,China)

机构地区：[1]南方医科大学附属南方医院创伤骨科,广东广州510515

出　　处：《中国骨质疏松杂志》2023年第5期751-757,共7页Chinese Journal of Osteoporosis

基　　金：国家自然科学基金重点项目(81830079)。

摘　　要：骨髓中的H型血管是与成骨活动高度耦联的骨髓血管亚型,特点是EMCN和CD31的高表达。H型血管在长骨发育的过程中在松质骨区形成,为生长板附近的细胞提供充足的营养支持,并通过旁分泌的方式影响前成骨细胞及破骨细胞的增殖及分化,提供适宜的微环境从而有利于新生骨的形成。由于H型血管与成骨活动有十分密切的关系,在骨折愈合、骨质疏松、骨关节炎、骨坏死以及肿瘤骨转移等骨疾病生理和病理过程中均有H型血管的参与,而针对H型血管的治疗可以改善上述疾病的进程。本文对H型血管与其耦联的成骨活动的机制进行了综述,有利于进一步了解H型血管在骨代谢中的作用,为从血管的角度理解骨疾病提供理论基础和思路。H-type blood vessel is a specialized bone marrow blood vessels that is highly coupled to osteogenic activity,characterized by high expression of EMCN and CD31.Type H vessels are formed in the cancellous bone area during long bone development to provide adequate nutritional support for cells near the growth plate and influencing the proliferation and differentiation of osteoprogenitors and osteoclasts in a paracrine manner,thus providing a suitable microenvironment to facilitate new bone formation.Because of the close relationship between H-type vessels and osteogenic activity,it has been found that H-type vessels are involved in the physiological and pathological processes of bone diseases such as fracture healing,osteoporosis,osteoarthritis,osteonecrosis,and tumor bone metastasis.Moreover,experimental treatments targeting H-type vessels can improve the outcome of these diseases.Here,we reviewed the molecular mechanisms related to H-type vessels and their coupled osteogenic activities.which are helpful to further understand the role of H-type vessels in bone metabolism and hopefully provide theoretical basis and ideas for understanding bone diseases from a vascular perspective.

关 键 词：H型血管 骨发育 骨疾病 成骨细胞 VEGF PDGF-BB 

分 类 号：R68[医药卫生—骨科学]