半乳糖凝集素1与动脉粥样硬化风险之间的因果关联:一项两样本孟德尔随机化研究  

Causal association between galectin-1 levels and the risk of atherosclerosis:a two-sample Mendelian randomization analysis

作　　者：崔瑞祥 王晓昱 左波 郭升[1] 赵晨昊 徐艳敏 赵国安[1] 艾思志 CUI Ruixiang;WANG Xiaoyu;ZUO Bo;GUO Sheng;ZHAO Chenhao;XU Yanmin;ZHAO Guoan;AI Sizhi(The First Affiliated Hospital of Xinxiang Medical University,Weihui,Henan 453100,China;Cardiovascular Center,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]新乡医学院第一附属医院,河南省卫辉市453100 [2]首都医科大学附属北京友谊医院心血管中心,北京市100050

出　　处：《中国动脉硬化杂志》2023年第5期419-426,共8页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学基金项目(U1904159);中国科学技术协会青年人才托举工程项目(2021QNRC001)。

摘　　要：[目的]探讨遗传预测的半乳糖凝集素1(Gal-1)水平与动脉粥样硬化(As)之间的因果关联。[方法]采用两样本孟德尔随机化(MR)研究方法,选择与Gal-1相关联的单核苷酸多态性(SNP)位点作为工具变量(IV),评估遗传预测的循环Gal-1水平与不同部位As风险的因果关联。[结果]逆方差加权法(IVW)分析结果显示,经过Bonferroni校正后遗传预测的循环Gal-1水平与外周动脉粥样硬化及其他部位动脉粥样硬化(除外脑动脉、冠状动脉及外周动脉)的风险呈正相关(OR=1.16,95%CI:1.05~1.27,P=0.002;OR=1.16,95%CI:1.12~1.20,P=4.11E-17),而与冠状动脉粥样硬化和脑动脉粥样硬化发生风险均未发现存在因果关联的证据(OR=1.02,95%CI:0.91~1.14,P=0.765;OR=1.10,95%CI:0.94~1.29,P=0.220);在应用荟萃分析合并上述不同部位As的效应值后,遗传预测的循环Gal-1水平与As风险呈正相关(OR=1.12,95%CI:1.06~1.19)。[结论]遗传预测的循环Gal-1水平与As的发病风险存在因果关联,Gal-1是预防As发生的潜在靶点。Aim To explore the potential causal association between galectin-1(Gal-1)levels and atherosclerosis(As).Methods Single nucleotide polymorphisms(SNP)associated with Gal-1 served as instrument variables(IV),and the causal association between genetically predicted Gal-1 levels and As was analyzed by the two-sample Mendelian randomization(MR)method.Results Inverse variance weighted(IVW)results showed that genetically predicted Gal-1 levels were positively associated with risk of peripheral As and other As type(excluding cerebral artery,coronary artery,and peripheral artery)after Bonferroni adjustment(OR=1.16,95%CI:1.05~1.27,P=0.002;OR=1.16,95%CI:1.12~1.20,P=4.11E-17).There was no evidence supporting the causal association between Gal-1 and either coronary As or cerebral As(OR=1.02,95%CI:0.91~1.14,P=0.765;OR=1.10,95%CI:0.94~1.29,P=0.220);After Meta-analyzed the MR estimates of As outcomes at different sites,the results showed that genetically predicted Gal-1 levels were positively associated with As risk(OR=1.12,95%CI:1.06~1.19).Conclusion The study suggests that genetically predicted Gal-1 level is causally associated with As risk,and Gal-1 is a potential target to prevent the occurrence of As.

关 键 词：半乳糖凝集素1 动脉粥样硬化 孟德尔随机化研究 因果关联 

分 类 号：R54[医药卫生—心血管疾病]