妊娠合并梅毒的流行病学特征及规范治疗对妊娠结局的影响  

Epidemiological Characteristics of Pregnancy Complicated with Syphilis and the Effect of Standardized Treatment on Pregnancy Outcome

作　　者：洪宏 王智慧[1] HONG Hong;WANG Zhi-hui(Department of Obstetrics and Gynecology,Suzhou Xiangcheng People's Hospital,Suzhou,Jiangsu,215131,China)

机构地区：[1]苏州市相城人民医院妇产科,江苏苏州215131

出　　处：《中国血液流变学杂志》2022年第4期595-598,共4页Chinese Journal of Hemorheology

摘　　要：目的分析妊娠合并梅毒孕产妇的一般特征,进一步证实规范治疗可以降低妊娠不良结局的发生,阻断梅毒母婴传播。方法选择2018年1月—2022年1月入院分娩的48例妊娠合并梅毒孕妇,根据孕期是否进行规范治疗分为规范治疗组与未规范治疗组,分析孕产妇的年龄、孕次、产次、户籍、学历、职业等一般特征,对比妊娠合并梅毒规范治疗与否对不良妊娠结局的影响。结果妊娠合并梅毒孕产妇中26~35岁组31例,占比65%。无职业者感染人数最多,占比65%;外地户籍感染人数明显大于本地户籍人数,占比为90%。初中及以下学历感染人数占比71%;性伴侣≥2名的人群感染梅毒的占比为69%,相对仅有1名性伴侣的人群感染概率明显增高。配偶患有梅毒者的感染率也明显高于配偶无梅毒者的感染率,占比为65%。规范治疗组中的早产、低出生体重、新生儿感染发生率显著低于未规范治疗组。结论妊娠合并梅毒感染严重危害孕产妇及胎儿的健康,针对重点人群加强健康宣教,规范治疗是控制梅毒母婴传播的有效方法。Objective To analyze the general characteristics of pregnant women with syphilis,further confirm that standardized treatment can reduce the occurrence of adverse pregnancy outcomes and block mother-to-child transmission of syphilis.Methods A total of 48 pregnant women with syphilis admitted to the hospital for delivery from January 2018 to January 2022 were selected and divided into a standard treatment group and a non-standard treatment group according to whether they received standard treatment or not during pregnancy.The general characteristics of pregnant women,such as age,gravidity,parity,household registration,education,occupation was analyzed,and the effect of standard treatment of pregnancy complicated with syphilis on adverse pregnancy outcomes was compared.Results Among pregnant women with syphilis,31 cases were in the group of 26-35 years old,accounting for 65%.The number of unemployed people infected was the largest,accounting for 65%.The number of non-locals was significantly larger than the locals accounting for 90%,the infected with their highest level of education as junior high school or lower accounting for 71%.The proportion infected with syphilis with more than 2 sexual partners was 69%,the probability of infection significantly higher than that of people with only one sexual partner.The infection rate of spouses with syphilis was also significantly higher than that of spouses without syphilis,accounting for 65%.The incidence of premature birth,low birth weight and neonatal infection in the standard treatment group was significantly lower than that in the non-standard treatment group(P<0.05).Conclusion Pregnancy complicated with syphilis infection seriously endangers the health of pregnant women and fetuses.Public health communication and education should be strengthened for focus groups.Standardized treatment is an effective method to control mother-to-child transmission of syphilis.

关 键 词：妊娠 梅毒 孕产妇 流行病学 妊娠结局 

分 类 号：R714.2[医药卫生—妇产科学] R759.1[医药卫生—临床医学]