脂肪动员过程中3种关键酶与肿瘤的相关性研究进展  

Research progress of three key enzymes in fat mobilization and their correlation with cancer

作　　者：许帅 张明[2] 高鑫 任聪聪(综述) 赵静(审校)[2] XU Shuai;ZHANG Ming;GAO Xin;REN Congcong;ZHAO Jing(Graduate School of Hebei North University,Zhangjiakou,Hebei 075000,China;Department of Oncology,Hebei General Hospital,Shijiazhuang,Hebei 050051,China;Graduate School of Ningxia Medical University,Yinchuan,Ningxia 750004,China)

机构地区：[1]河北北方学院研究生学院,河北张家口075000 [2]河北省人民医院肿瘤科,河北石家庄050051 [3]宁夏医科大学研究生学院,宁夏银川750004

出　　处：《国际检验医学杂志》2023年第10期1265-1269,共5页International Journal of Laboratory Medicine

基　　金：河北省人才工程培养项目(A201903002);河北省医学科学研究重点课题(20180013)。

摘　　要：代谢重编程是恶性肿瘤细胞的标志性特征之一。活跃的脂代谢产生大量脂质,为肿瘤细胞提供了生物膜结构的基本原料分子、营养支持和能量供给,并合成多种促癌信号分子,从而促进肿瘤细胞的生长增殖、迁移及侵袭。脂肪动员是脂肪分解的第一步,该过程中关键酶的表达异常,是脂代谢重编程的重要组成部分。研究发现,脂肪动员通路中的关键酶脂肪甘油三酯脂肪酶(ATGL)、激素敏感脂肪酶(HSL)和单酰甘油脂肪酶(MAGL)在多种恶性实体瘤表达异常,并且通过干预这些酶的表达能够显著改善肿瘤细胞的恶性生物学行为。因此,通过靶向脂肪动员通路中的关键酶,改善肿瘤细胞的脂代谢重编程从而产生抗肿瘤作用,有望为肿瘤治疗提供新的靶点和方向。作者综述了脂肪动员过程中的3种关键酶与肿瘤的相关性,探索抗肿瘤治疗的新理论,为开展相关性研究提供依据。Metabolic reprogramming is one of the hallmark features of malignant tumor cells.Active lipid metabolism produces large amounts of lipids,which provide the basic raw material molecules for biofilm structure,nutritional support,energy supply for the biofilm structure of tumor cells.Metabolic reprogramming is one of the signature features of malignant tumor cells and synthesize a variety of cancer-promoting signal molecules,thus promoting the growth,proliferation,migration,and invasion of tumor cells.Fat mobilization is the first step in fat decomposition,during which the abnormal expression of key enzymes is an important part of fat metabolism reprogramming.It has been found that key enzymes ATGL,HSL and MAGL in fat mobilization pathway are abnormally expressed in a variety of malignant solid tumors,and the malignant biological behavior of tumor cells can be significantly improved by interfering with the expression of these enzymes.Therefore,it is expected to provide new targets and directions for tumor therapy by targeting key enzymes in the fat mobilization pathway to improve the lipid metabolism reprogramming of tumor cells and thus generate anti-tumor effects.The authors review the correlation between the three key enzymes in fat mobilization and tumor in order to explore new theories of anti-tumor therapy and provide a basis for correlation studies.

关 键 词：脂肪动员 脂肪甘油三酯脂肪酶 激素敏感脂肪酶 单酰甘油脂肪酶 

分 类 号：R542.2[医药卫生—心血管疾病]