Klotho在心力衰竭中作用的研究进展  

Research progress on the role of Klotho in heart failure

作　　者：柴亚如 邓玉婷 戴红艳[2] 管军[3] CHAI Yaru;DENG Yuting;DAI Hongyan;GUAN Jun(School of Clinical Medicine,Weifang Medical College,Weifang 261000;Department of Healthcare Cardiology,Qingdao Municipal Hospital,Qingdao 266000,China;Department of Cardiology,Qingdao Municipal Hospital,Qingdao 266000,China)

机构地区：[1]潍坊医学院临床医学院,山东潍坊261000 [2]青岛市市立医院保健心内科,山东青岛266000 [3]青岛市市立医院心内科,山东青岛266000

出　　处：《基础医学与临床》2023年第6期998-1002,共5页Basic and Clinical Medicine

基　　金：青岛市科技惠民示范引导专项(21-1-4-rkjk-9-nsh);青岛市医疗卫生优秀学科带头人项目(青卫科教字[2019]9号)。

摘　　要：Klotho是一种抗衰老蛋白,可分为全长跨膜型Klotho、可溶性Klotho和分泌型Klotho 3种类型,其与氧化应激、炎性反应、心肌肥厚与纤维化、自噬、线粒体功能障碍等联系密切,参与抑制了心力衰竭的发生发展,有望为心力衰竭的治疗提供新的靶点和方向。Klotho is an anti-aging protein and can be divided into three types:full-length transmembrane Klotho,soluble Klotho and secreted Klotho.Many studies have shown that Klotho is closely related to oxidative stress,inflammatory response,myocardial hypertrophy,fibrosis,autophagy,and mitochondrial dysfunction.It is also involved in the occurrence and development of heart failure.It is expected to provide a new target and direction for the treatment of heart failure.

关 键 词：KLOTHO 抗衰老蛋白 心力衰竭 

分 类 号：R542[医药卫生—心血管疾病]