子宫内膜葡萄糖转运体在胚胎着床中作用的研究进展  

Research progress on the role of endometrial glucose transporters in embryo implantation

作　　者：张立雪[1] 李长兴[2] ZHANG Lixue;LI Changxing(Department of Medicine,Northwest Minzu University,Lanzhou 730000;Medical Institute of Qinghai University,Xining 810001,China)

机构地区：[1]西北民族大学医学部,甘肃兰州730000 [2]青海大学医学院,青海西宁810001

出　　处：《基础医学与临床》2023年第6期1003-1007,共5页Basic and Clinical Medicine

基　　金：2022年度甘肃省高等学校青年博士基金(2022QB-026);2022年校级本科人才培养质量提高项目(2022XJJG-89);2022年校级创新创业教育改革项目(2022XJCXCYJGXM16)。

摘　　要：葡萄糖转运体是介导葡萄糖跨细胞膜转运的重要载体,分为易化扩散葡萄糖转运体(GLUTs)和钠-葡萄糖协同转运体(SGLTs)以及尚待深入研究的一类葡萄糖转运体SWEETS。胚胎着床过程中子宫内膜上皮细胞葡萄糖的摄取与利用可保障与着床相关功能活动得以正常运行。本文就葡萄糖转运体在胚胎着床中的作用进行阐述,旨在揭示胚胎着床的机制,为着床失败导致的女性不孕及早期流产的诊断治疗提供新的思路。Glucose transporters are important carriers that mediate glucose transport across cell membranes,including facilitated diffusion glucose transporters(GLUTs),sodium glucose co transporters(SGLTs),and a class of glucose transporters SWEETs that have not been extensively studied.Glucose uptake and utilization of endometrial epithelial cells during implantation can ensure normal implant-related functional activities.The purpose of this paper is to elucidate the role of glucose transporter in embryo implantation in order to further reveal the mechanism of embryo implantation and provide new ideas for the diagnosis and treatment of female infertility and early abortion caused by implantation failure.

关 键 词：子宫内膜 葡萄糖转运体 胚胎着床 

分 类 号：R339.22[医药卫生—人体生理学]