铁死亡在新生儿急性肺损伤中作用机制的研究进展  

Research progress on the mechanism of ferroptosis in neonatal acute lung injury

作　　者：楚晓云 蔡成 CHU Xiaoyun;CAI Cheng(Department of Neonatology,Shanghai Children s Hospital,School of Medicine,Shanghai Jiao Tong University,Shanghai 200062,China)

机构地区：[1]上海市儿童医院、上海交通大学医学院附属儿童医院新生儿科,上海200062

出　　处：《基础医学与临床》2023年第6期1008-1011,共4页Basic and Clinical Medicine

基　　金：上海市儿童医院院级课题国家自然科学基金培育专项(2020YGZQ01)。

摘　　要：急性肺损伤是新生儿中常见的一种危急重症,铁死亡作为一种新型细胞程序性死亡形式,可通过调节铁稳态、氨基酸代谢和脂质过氧化反应参与急性肺损伤的进程。深入研究铁死亡在急性肺损伤中的作用机制可为其防治提供新思路。Acute lung injury is a common critical illness in neonates.Ferroptosis,a novel form of programmed cell death,plays an important role in the process of acute lung injury by regulating iron homeostasis,metabolism of amino acid and lipid peroxidation.In-depth study of the mechanism of ferroptosis in acute lung injury may provide new ideas for its prevention and treatment.

关 键 词：铁死亡 铁稳态 氨基酸代谢 脂质过氧化 新生儿急性肺损伤 

分 类 号：R725.6[医药卫生—儿科]