Assessment of risks, implications, and opportunities of waterborne neurotoxic pesticides  

作　　者：Delaram Dara Andrei P.Drabovich 

机构地区：[1]Division of Analytical and Environmental Toxicology,Department of Laboratory Medicine and Pathology,Faculty of Medicine and Dentistry,University of Alberta,Alberta T6G 2G3,Canada

出　　处：《Journal of Environmental Sciences》2023年第3期735-741,共7页环境科学学报（英文版）

摘　　要：Pesticides are a well-known family of chemicals that have contaminated water systems globally. Four common subfamilies of pesticides include organochlorines, organophosphates, pyrethroids, and carbamate insecticides which have been shown to adversely affect the human nervous system. Studies have shown a link between pesticide exposure and decreased viability, proliferation, migration, and differentiation of murine neural stem cells. Besides human exposure directly through water systems, additional factors such as pesticide bioaccumulation, biomagnification and potential synergism due to co-exposure to other environmental contaminants must be considered. A possible avenue to investigate the molecular mechanisms and biomolecules impacted by the various classes of pesticides includes the field of-omics. Discovery of the precise molecular mechanisms behind pesticidemediated neurodegenerative disorders may facilitate development of targeted therapeutics.Likewise, discovery of pesticide biodegradation pathways may enable novel approaches for water system bioremediation using genetically engineered microorganisms. In this minireview, we discuss recently established harmful impacts of various categories of pesticides on the nervous system and the application of-omics field for discovery, validation, and mitigation of pesticide neurotoxicity.

关 键 词：Neurotoxic pesticides Water pollution Neural stem cells Omics approaches Drug discovery 

分 类 号：X592[环境科学与工程—环境工程]