Polyhalogenated carbazoles induce hepatic metabolic disorders in mice via alteration in gut microbiota  

作　　者：Chenyang Ji Yunkai Luo Jiawen Yang Yaoyao Dai Jiahui Miao Siqing Yue Meirong Zhao 

机构地区：[1]Key Laboratory of Pollution Exposure and Health Intervention of Zhejiang Province,Interdisciplinary Research Academy,Zhejiang Shuren University,Hangzhou 310015,China [2]Department of Ultrasound in Medicine,The Fourth Affiliated Hospital of Zhejiang University School of Medical,Yiwu 322000,China [3]Key Laboratory of Microbial Technology for Industrial Pollution Control of Zhejiang Province,College of Environment,Zhejiang University of Technology,Hangzhou 310014,China

出　　处：《Journal of Environmental Sciences》2023年第5期603-614,共12页环境科学学报（英文版）

基　　金：supported by Joint Innovation Fund for Regional Development of National Natural Science Foundation of China(No.U20A20134);Leading Talent of Technological Innovation of Ten-Thousands Talents Program of Zhejiang Province(No.2020R52012).

摘　　要：Polyhalogenated carbazoles(PHCZs)have been widely accepted as emerging pollutants,whereas their ecological and health risks remain uncertain.Herein,female and male Sprague-Dawley(SD)mice were treated with four typical PHCZs to investigate their negative consequences,along with alternations in gutmicrobiota to indicate underlyingmechanisms.In female mice,the relative liver weight ratio increased after four PHCZs exposure;2-bromocarbazole(2-BCZ)increased urine glucose level;3-bromocarbazole(3-BCZ)decreased the glucose and total cholesterol levels;3,6-dichlorocarbazole(3,6-DCCZ)decreased glucose level.The only disturbed biochemical index in male mice was the promoted alkaline phosphatase(ALP)level by 3,6-DCCZ.We also found that the differential blood biochemical indices were correlated with gut microbiota.3-BCZ and 3,6-DCCZ altered Bacteroidetes and Proteobacteria phyla in female and male mice,which were correlated with metabolic disorders.Our findings demonstrated the correlation between PHCZs induced potential hepatotoxicity andmetabolic disordersmay be due to their dioxin-like potentials and endocrine disrupting activities,and the gender differences might result from their estrogenic activities.Overall,data presented here can help to evaluate the ecological and health risks of PHCZs and reveal the underlying mechanisms.

关 键 词：Polyhalogenated carbazoles LIVER Metabolic disorders Gut microbiota 

分 类 号：X503[环境科学与工程—环境工程]