检测硫化氢近红外荧光探针研究进展  

Research Progress of Near Infrared Fluorescence Probe for Detecting Hydrogen Sulfide

作　　者：黄红莲 HUANG Hong-lian(Yunnan Normal University,Kunming Yunnan 650500,China)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500

出　　处：《辽宁化工》2023年第5期743-745,749,共4页Liaoning Chemical Industry

摘　　要：用于监测活细胞和生物体中H2S水平的荧光探针是非常可取的。在这方面,近红外(NIR)荧光探针已成为一种有前途的工具。NIR-Ⅰ和NIR-Ⅱ探针有许多显著的优点;例如,近红外光比可见光穿透组织更深,在生物样品分析过程中造成的光损伤更小,自身荧光更少,从而实现更高的信本比。因此,在近红外区域发射的荧光探针有望更适合于活体成像。因此,在文献中出现了大量新的H2S响应近红外荧光探针的报道。综述了近年来用于生物样品中H2S的近红外荧光探针的研究进展。重点介绍了它们在实时监测细胞内H2S和活体细胞/动物生物成像中的应用。A fluorescent probe for monitoring H2S levels in living cells and organisms is highly desirable.In this regard,near-infrared(NIR)fluorescent probes have become a promising tool.NIR-I and NIR-II probes have many significant advantages,for example,near-infrared light penetrates tissues more deeply than visible light,causing less light damage and less self-fluorescence during the analysis of biological samples,resulting in a higher letter-to-letter ratio.Therefore,fluorescent probes emitted in the near-infrared region are expected to be more suitable for in vivo imaging.As a result,there have been a large number of reports of new H2S-responsive near-infrared fluorescent probes in the literature.In this paper,recent research advances in near-infrared fluorescent probes for H2S in biological samples were reviewed.Their application in real-time monitoring of intracellular H2S and live cell/animal biological imaging was discussed.

关 键 词：荧光 硫化氢 近红外探针 生物成像 

分 类 号：O657[理学—分析化学]