绝经前后子宫内膜样癌与代谢综合征相关性研究  

Metabolic Syndrome May Associate with Younger Endometrioid Carcinoma

作　　者：薛丽芳[1] 王丽莹 蔡良知[1] XUE Lifang;WANG Liying;CAI Liangzhi(Fujian Maternity and Child Health Hospital,Fujian Key Laboratory of Women and Children's Critical Diseases Research,Fujian Maternity and Child Health Hospital,Fuzhou 350000,China)

机构地区：[1]福建省妇幼保健院/福建省妇儿重大疾病研究重点实验室,福建福州350000

出　　处：《中国医药指南》2023年第14期26-29,共4页Guide of China Medicine

摘　　要：目的探讨绝经前和绝经后子宫内膜样癌患者代谢综合征及其组分和临床病理特征的差异。方法选取2017年12月至2021年12月在福建省妇幼保健院接受治疗的子宫内膜样癌患者318例,根据是否绝经将患者分为绝经前和绝经后组,对其临床数据进行回顾性分析。结果绝经前与绝经后组代谢综合征和肥胖发病率差异无统计学意义(P>0.05);绝经前组脂代谢异常发病率高于绝经后组(P<0.05);绝经后组糖尿病、高血压发病率均明显高于绝经前组,差异有统计学意义(P<0.05)。临床分期、病理分级、深肌层浸润、淋巴结转移在绝经前后组中差异无统计学意义(P>0.05)。以是否有代谢综合征分为两组,两组间FIGO分期、病理分级、深肌层浸润、淋巴结转移的占比差异有统计学意义(P<0.05)。结论绝经前后子宫内膜样患者代谢综合征患病率相当,代谢综合征患者肿瘤侵袭性强,与子宫内膜样癌预后不良相关。绝经前子宫内膜样癌患者代谢综合征以肥胖、血脂紊乱为主,高血压、糖尿病发生率低,临床应重视代谢紊乱的纠正、雌激素的拮抗。Objective To investigate the difference in the incidence of metabolic syndrome and its components,pathological features between premenopausal and postmenopausal endometrioid carcinoma patients.Methods A total of 318 patients with endometrioid carcinoma who received treatment in Fujian Maternal and Child Health Hospital from December 2017 to December 2021 were selected and their clinical data were retrospectively analyzed.According to whether they were menopausal or not,these patients were divided into premenopausal and postmenopausal group.Results There was no differences in metabolic syndrome and obesity incidence between the premenopausal and postmenopausal group(P>0.05).The morbidity of lipid metabolic disorder in the premenopausal group was higher than postmenopausal group(P<0.05).While the incidence of diabetes and high blood pressure in postmenopausal group were significantly higher than premenopausal group,There was significant difference(P<0.05).There were no significant differences in clinical stage,pathological grade,deep muscle infiltration and lymph node metastasis among postmenopausal groups(P>0.05).The two groups were divided into two groups according to whether there was metabolic syndrome or not,and the proportions of FIGO stage,pathological grade,deep muscle infiltration and lymph node metastasis were statistically different between the two groups(P<0.05).Conclusion The prevalence of metabolic syndrome in postmenopausal endometrioid patients is similar,and the tumor aggressiveness in patients with metabolic syndrome is strongly associated with poor prognosis of EC.The metabolic syndrome of premenopausal EC patients is mainly obesity and dyslipidemia,and the incidence of hypertension and diabetes is low.We should pay attention to the correction of metabolic disorders and the antagonism of estrogen.

关 键 词：子宫内膜样癌 绝经 代谢综合征 代谢异常 

分 类 号：R711.74[医药卫生—妇产科学]