阿奇霉素治疗小儿肺炎支原体肺炎的效果  

Effect Azithromycin for Pediatric Mycoplasma Pneumoniae Pneumonia

作　　者：朱如旺 王丁峰 江升 ZHU Ruwang;WANG Dingfeng;JIANG Sheng(Fuqing Maternal and Child Health Care Hospital,Fuqing 350300,China)

机构地区：[1]福清市妇幼保健院,福建福清350300

出　　处：《中国医药指南》2023年第14期46-49,共4页Guide of China Medicine

摘　　要：目的 观察小儿肺炎支原体肺炎采取阿奇霉素治疗的临床治疗效果。方法 选取2021年8月至2022年8月收治的67例小儿肺炎支原体肺炎患儿作为研究对象,借助随机数表法加以分组处理,研究方式为回顾性研究,对照组(n=34)选取常规药物治疗,观察组(n=33)选取阿奇霉素治疗。比较两组的治疗效果。结果 观察组体温恢复时间、咳痰消失时间、咳嗽消失时间、畏寒消失时间以及住院时间均短于对照组,差异有统计学意义(P <0.05);治疗前,两组患儿的免疫指标(IgG、IgA)比较差异无统计学意义(P> 0.05),治疗后观察组患儿免疫指标(IgG、IgA)高于对照组,差异有统计学意义(P <0.05);治疗前两组患儿炎性指标(TNF-α、Hs-CRP、IL-6)比较差异无统计学意义(P> 0.05),治疗后观察组患儿炎性指标(TNF-α、Hs-CRP、IL-6)低于对照组,差异有统计学意义(P <0.05);观察组治疗有效率、治疗满意度高于对照组,不良反应发生率低于对照组,差异有统计学意义(P <0.05);治疗前两组患儿肺功能指标(V-T、FEV_(1)、PEF)比较差异无统计学意义(P> 0.05),治疗后观察组患儿肺功能指标(V-T、FEV_(1)、PEF)高于对照组,差异有统计学意义(P <0.05)。结论 采取阿奇霉素治疗小儿肺炎支原体肺炎患儿,在改善临床症状、提升治疗效果、优化满意度方面具有显著的意义,可有效提升患儿肺功能,有利于提高患儿免疫力,减轻炎性反应,确保患儿临床治疗的安全性。Objective To observe the clinical treatment effect of azithromycin treatment for mycoplasma pneumoniae pneumonia in children.Methods In this paper,67 children with mycoplasma pneumoniae admitted from August 2021 to August 2022 were selected as research subjects and grouped by random number table method.The study method was retrospective study,and the control group(n=34)selected conventional drug therapy,and the observation group(n=33)selected azithromycin treatment.The effect of two groups were compared.Results The time of temperature recovery,expectoration disappearance,cough disappearance,chills disappearance and hospitalization time were lower than that of the control group,the difference was statistically significant(P<0.05).There was no significant difference in the immune indexes(IgG,IgA)between the two groups of children before treatment(P>0.05).The immune index(IgG,IgA)were higher in the control group,the difference was statistically significant(P<0.05).The inflammatory indicators(TNF-α,Hs-CRP,IL-6)between the two groups before treatment were insignificant(P>0.05),lower inflammatory indicators(TNF-α,Hs-CRP,IL-6)than those of the control group,the difference was statistically significant(P<0.05).Treatment efficiency and treatment satisfaction in the observation group were higher than those in the control group,adverse reactions were lower than those in the control group,the difference was statistically significant(P<0.05).There was no significant difference in pulmonary function indexes(V-T,FEV1 and PEF)between the two groups before treatment(P>0.05).The indexes of pulmonary function(V-T,FEV1,PEF)in the post-treatment observation group were higher than that in the control group,the difference was statistically significant(P<0.05).Conclusion For children with mycoplasma pneumoniae pneumonia,azithromycin treatment is of great significance in improving the clinical symptoms,improving the treatment effect and optimizing the satisfaction.It can effectively improve the lung function of children,improve the imm

关 键 词：小儿肺炎支原体肺炎 阿奇霉素 免疫指标 炎性指标 

分 类 号：R563.1[医药卫生—呼吸系统]