克立硼罗软膏治疗特应性皮炎患儿的安全性  

Safety of Crisaborole Ointment in Children with Atopic Dermatitis

作　　者：张秀钦 程波[2] 方芳[2] ZHANG Xiuqin;CHEN Bo;FANG Fang(Department of Dermatological,Xiamen Haicang Hospital,Xiamen 361026,China;Department of Dermatological,the First Affiliated Hospital of Fujian Medical University,Fuzhou 350001,China)

机构地区：[1]厦门市海沧医院皮肤科,福建厦门361026 [2]福建医科大学附属第一医院皮肤科,福建福州350001

出　　处：《中国医药指南》2023年第14期89-91,共3页Guide of China Medicine

摘　　要：目的 探究克立硼罗软膏治疗特应性皮炎(AD)患儿的安全性。方法 选取2021年2月至2022年2月就诊于医院的92例AD患儿,按随机数表法分为两组,各46例。对照组采用丁酸氢化考的松乳膏,观察组采用克立硼罗软膏,均治疗2周。比较两组治疗2周的临床疗效。比较两组治疗前、治疗2周的皮损程度[AD积分指数(SCORAD)]、炎性因子[白细胞介素-6(IL-6)、肿瘤坏死因子α(TNF-α)]、生活质量[儿童皮肤病生活质量指数(CDLOI)]。比较两组临床症状消失时间及不良反应发生情况。结果治疗2周,观察组的总有效率比对照组高(P <0.05);治疗2周,两组SCORAD评分、CDLQI评分低于治疗前,观察组比对照组低(P <0.05);治疗2周,两组IL-6、TNF-α水平低于治疗前,观察组比对照组低(P <0.05)。观察组红斑、水肿及瘙痒消失时间均短于对照组(P <0.05)。两组不良反应发生率比较,差异无统计学意义(P> 0.05)。结论 克立硼罗软膏可有效减轻AD患儿的皮损程度及炎性反应,加快临床症状消失,改善患儿的生活质量,且不良反应较少,安全性较高。Objective To explore the safety of crisaborole ointment in children with atopic dermatitis(AD).Methods The 92 children with AD diagnosed and treated in our hospital from February 2021 to February 2022 were divided into two groups,including 46 patients of each group.In the control group,pine cream with a hydrobutyrate test was used,and the observation group used the crisaborole ointment,and all patients were treated for 2 weeks.To compare the clinical efficacy of the two groups for 2 weeks;to compare the degree of skin loss[AD integral index(SCORAD)],inflammatory cytokines[interleukin-6(IL-6),tumor necrosis factorα(TNF-α)],quality of life[pediatric skin disease quality of life index(CDLOI)];and to compare the disappearance time of clinical symptoms and adverse reactions between the two groups.Results For 2 weeks of treatment,the observation group was more effective than the control group(P<0.05),with lower SCORAD and CDLQI scores than before treatment(P<0.05),and for 2 weeks of treatment,lower IL-6 and TNF-αlevels were lower than before treatment(P<0.05).The disappearance of erythema,edema and pruritus in the observation group were shorter than the control group(P<0.05).No significant difference was found between the two adverse reaction groups(P>0.05).Conclusion Crisaborole ointment can effectively reduce the degree of skin damage and inflammation in AD children,accelerate the disappearance of clinical symptoms,and improve the quality of life of the children,with fewer adverse reactions and high safety.

关 键 词：特应性皮炎 克立硼罗软膏 丁酸氢化考的松 皮损 生活质量 不良反应 

分 类 号：R753.2[医药卫生—皮肤病学与性病学]