阿托伐他汀联合常规疗法用于糖尿病肾病患者的效果  

Effects of Atorvastatin combined with conventional therapy on patients with diabetic nephropathy

作　　者：董玉国 DONG Yuguo(Emergency Department of the Central Hospital of Jiamusi City,Jiamusi 154002 Heilongjiang,China)

机构地区：[1]佳木斯市中心医院急诊科,黑龙江佳木斯154002

出　　处：《中国民康医学》2023年第8期33-35,共3页Medical Journal of Chinese People’s Health

摘　　要：目的:观察阿托伐他汀联合常规疗法用于糖尿病肾病患者的效果。方法:选取2019年6月至2021年6月114例糖尿病肾病患者进行前瞻性研究,按照随机数字表法分为观察组与对照组各57例。对照组给予常规疗法,观察组在对照组基础上给予阿托伐他汀钙片治疗,比较两组临床疗效、血浆微循环障碍指标[纤维蛋白原(FIB)、内皮素-1(ET-1)、血栓素(TXB2)]水平、血浆肾脏纤维化指标[层粘蛋白(LN)、Ⅲ型前胶原(PCⅢ)、Ⅳ型胶原(CⅣ)]水平和治疗期间不良反应发生率。结果:观察组治疗总有效率为78.95%,明显高于对照组的59.65%,差异有统计学意义(P<0.05);治疗后,两组血浆FIB、ET-1、TXB2、LN、PCⅢ和CⅣ水平均低于治疗前,且观察组低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规疗法基础上采用阿托伐他汀治疗糖尿病肾病患者可提高治疗总有效率,降低微循环障碍指标和肾脏纤维化指标水平,效果优于单纯常规疗法。Objective:To observe effects of Atorvastatin combined with conventional therapy on patients with diabetic nephropathy.Methods:A prospective study was conducted on 114 patients with diabetic nephropathy from June 2019 to June 2021.They were divided into observation group and control group according to the random number table method,57 cases in each group.The control group was given conventional therapy,while the observation group was treated with Atorvastatin calcium tablets on the basis of that of the control group.The clinical efficacy,the plasma microcirculation disturbance index levels[fibrinogen(FIB),endothelin-1(ET-1),thromboxane(TXB2)]levels,the plasma renal fibrosis index levels[laminin(LN),type III procollagen(PCIII),type IV collagen(CIV)],and the incidence of adverse reactions during the treatment were compared between the two groups.Results:The total effective rate of treatment in the observation group was 78.95%,which was significantly higher than 59.65%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of plasma FIB,ET-1,TXB2,LN,PCIII and CIV in the two groups were lower than those before the treatment,those in the observation group were lower than those in the control group,and the differences were statistically significant(P<0.05).However,there was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of the conventional therapy,Atorvastatin can improve the total effective rate of treatment in the patients with diabetic nephropathy,and reduce the levels of microcirculation disturbance indexes and renal fibrosis indexes.Moreover,it is superior to single conventional therapy.

关 键 词：阿托伐他汀 糖尿病肾病 纤维蛋白原 内皮素-1 血栓素 层粘蛋白 Ⅲ型前胶原 

分 类 号：R587.2[医药卫生—内分泌]