妊娠期糖尿病患者血清D-D、NO、NOS水平及预测产后出血  

Levels of serum D dimer,nitric oxide,nitric oxide synthase of pregnant women with gestational diabetes mellitus and their prediction in the postpartum hemorrhage of the women

作　　者：李甜甜 高金菊 黄启玉 LI Tiantian;GAO Jinju;HUANG Qiyu(The Second People's Hospital of Jingmen,Hubei Province,448000)

机构地区：[1]湖北省荆门市第二人民医院,448000

出　　处：《中国计划生育学杂志》2023年第5期1196-1199,共4页Chinese Journal of Family Planning

摘　　要：目的:分析血清一氧化氮合成酶(NOS)、D-二聚体(D-D)、一氧化氮(NO)水平与妊娠期糖尿病(GDM)产后出血关系。方法:选择2019年1月-2021年8月本院收治的GDM产妇212例临床资料,根据是否发生产后出血分为出血组(n=54)和非血组(n=158)。比较两组D-D、NO、NOS水平及相关临床资料,通过受术者工作特征曲线(ROC)分析血清D-D、NO、NOS水平预测GDM患者产后出血的价值,采用logistic分析妊娠期糖尿病患者产后出血的危险因素。结果:产后出血组D-D(1628.32±69.55μg/L)、NO(110.54±30.18μmol/L)、NOS(26.78±4.18 U/ml)水平均高于非出血组(851.02±45.65μg/L、62.15±10.60μmol/L、19.04±4.03 U/ml)(均P<0.05);ROC曲线分析,D-D、NO、NOS预测GDM患者产后出血的曲线下面积分别为0.810、0.820、0.765;D-D、NO、NOS水平升高是GDM患者产后出血的独立危险因素,D-D与NO、NOS呈正相关关系,NO与NOS正相关关系(均P<0.05)。结论:血清D-D、NO、NOS水平与GDM产后出血发生相关,且异常升高对预测患者产后出血具有临床价值。Objective:To study the correlation between the levels of serum D dimer(D D),nitric oxide(NO),nitric oxide synthase(NOS)of pregnant women with gestational diabetes mellitus(GDM)and the risk of their postpartum hemorrhage(PH).Methods:The clinical data of 212 pregnant women with GDM from January 2019 to August 2021 were selected in this study.According to the occurrence of PH,these women were divided into group A(54 women with PH)and group B(158 women without PH).The levels of D D,NO,and NOS,and other general data of the women were compared between the two groups.The levels of serum D D,NO,and NOS of the women with GDM for predicting their PH was analyzed by receiver operator characteristic(ROC)curve,and the risk factors of PH of the women with GDM were analyzed by Logistic analysis.Results:The levels of D D(1628.32±69.55 mu g/L),NO(110.54±30.18 u mol/L),and NOS(26.78±4.18 mm U/ml)of the women in group A were significantly higher than those(851.02±45.65μg/L,2.15±10.60pmol/L,and 19.04±4.03 U/ml)of the women in group B(all P<0.05).ROC curve analysis showed that the area under the curve of the levels of D D,NO,and NOS of the women with GDM for predicting their PH were 0.810,0.820,0.765,respectively,and the increase of the levels of DD,NO,and NOS of the women were their independent risk factorsof PH.The D D level of the women with GDM was positively correlated with their NO and NOS levels,and the NO level of the women with GDM was positively correlated with their NOS level(P<0.05).Conclusion:The levels of serum D D,NO,and NOS of the women with GDM are related to their PH,and the abnormal increase of which have clinical values of the women with GDM for predicting their PH.

关 键 词：妊娠期糖尿病 产后出血 D-二聚体 一氧化氮 一氧化氮合成酶 预测 

分 类 号：R714.256[医药卫生—妇产科学] R714.461[医药卫生—临床医学]