糖调节受损周围神经病变的神经电生理特征性分析研究  

Neuroelectrophysiological Characteristics of Peripheral Neuropathy with Impaired Glucose Regulation

作　　者：葛晶[1] 邹丽 付春艳 陶萍 刘莉 GE Jing;ZOU Li;FU Chunyan(Chengde Central Hospital,Hebei Chengde 0670000,China)

机构地区：[1]河北省承德市中心医院,河北承德067000

出　　处：《河北医学》2023年第5期855-861,共7页Hebei Medicine

基　　金：2022年承德市科学技术研究与发展项目:(编号:202204A149)。

摘　　要：目的:探讨糖调节受损周围神经病变的神经电生理特征性分析,联合多伦多临床评分系统对糖调节受损合并周围神经病变的诊断价值,为临床医师提供早期发现糖调节受损患者的周围神经病变资料。方法:选取2021年1月至2022年12月我院收治的200例受试者资料作为研究组,所有受试者的多伦多临床评分系统均不低于6分。其中空腹血糖受损患者68例,糖耐量异常患者66例,2型糖尿病患者66例。将其分为三组,即空腹血糖受损+周围神经病变-A组,糖耐量异常+周围神经病变-B组和糖尿病周围神经病变-C组。同时选取同期200例健康体检者作为对照组。结果:感觉神经传导检测中可见,研究组正中神经SCV、SNAP波幅明显低于对照组,经统计学分析差异有统计学意义(P<0.05);C组正中神经SCV、SNAP波幅较A组、B组和对照组均显著降低;研究组腓肠神经和腓浅神经SNAP波幅显著降低,与对照组比较差异有统计学意义(P<0.05);B组和C组的腓浅神经和腓肠神经SCV均降低,与对照组比较有统计学意义(P<0.05);对照组与A组腓肠神经及腓浅神经SCV比较无统计学意义(P>0.05);C组正中、腓浅、腓肠神SNAP波幅及SCV均显著低于A组,经统计下分析有统计学意义(P<0.05);A组、B组、C组及对照组尺神经SNAP及SCV波幅经统计学分析无统计学意义(P>0.05)。运动神经传导检测中可见;C组正中神经、胫神经以及腓总神经MCV、CMAP波幅相比对照组有显著降低,DML与对照组比较可见延长(P<0.05);B组与对照组相比可见,正中神经、胫神经、腓总神经CMAP波幅显著降低,DML可见延长,腓总神经、正中神经MCV显著降低(P<0.05);A组正中神经MCV、胫神经CMAP波幅明显低于对照组,有统计学意义(P<0.05);C组正中神经和腓总神经CMAP波幅、胫神经MCV、DML延长相比A组,明显减慢(P<0.05);B组费用神经CMAP波幅与A组相比较显著降低,DML有延长(P<0.05)。A组、B组、C组中尺神Objective:To investigate the characteristic neurophysiological analysis of peripheral neuropathy with impaired glucose regulation and the diagnostic value of the Toronto Clinical Scoring System for the combination of peripheral neuropathy with impaired glucose regulation,and to provide clinicians with information for the early detection of peripheral neuropathy in patients with impaired glucose regulation.Methods:The data of 200 subjects admitted to our hospital from January 2021 to December 2022 were selected as the study group,and all subjects had a score of no less than 6 on the Toronto Clinical Scoring System.There were 68 patients with impaired fasting glucose,66 patients with abnormal glucose tolerance and 66 patients with type 2 diabetes mellitus.They were divided into three groups,namely impaired fasting glucose+peripheral neuropathy-group A,abnormal glucose tolerance+peripheral neuropathy-group B and diabetic peripheral neuropathy-group C.Meanwhile,200 cases of healthy physical examiners were selected as the control group during the same period.Results:As seen in the sensory nerve conduction test,the SCV and SNAP wave amplitudes of the median nerve in the study group were significantly lower than those of the control group,and the difference was statistically significant by statistical analysis(P<0.05);the SCV and SNAP wave amplitudes of the median nerve in group C were significantly lower than those of groups A,B and the control group;the SNAP wave amplitudes of the gastrocnemius and superficial peroneal nerve in the study group were significantly lower,and the difference was statistically significant when compared with the control group(P<0.05);superficial peroneal nerve and peroneal nerve SCV were reduced in both groups B and C,which were statistically significant when compared with the control group(P<0.05);there was no statistically significant difference between the control group and group A in terms of peroneal nerve and superficial peroneal nerve SCV(P>0.05);median,superficial peroneal and perone

关 键 词：糖调节受损 神经传导检测 周围神经病变 糖化血红蛋白 

分 类 号：R587.2[医药卫生—内分泌]