SNRIs类药物在神经病理性疼痛中的临床应用进展  

Research Progress of the Clinical Application of SNRIs in Neuropathic Pain

作　　者：赵丽玲 黄彦珊 王利[1,4] 刘书豪 王婧 ZHAO Liling;HUANG Yanshan;WANG Li;LIU Shuhao;WANG Jing(Department of Pharmacy,Shanghai Sixth People's Hospital Affiliated to School of Medicine,Shanghai Jiaotong University,Shanghai 200233,China;Department of Pharmacy,Henan Provincial Chest Hospital,Zhengzhou University,Zhengzhou 450000,China;Department of Pharmacy,Wuyi Hospital of Traditional Chinese Medicine,Jiangmen City,Guangdong Province,Jiangmen 529000,China;Department of Pharmacy,Affiliated Hospital of Jining Medical University,Jining 272007,China;Department of Pharmacy,the First Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]上海交通大学医学院附属第六人民医院药剂科,上海200233 [2]河南省胸科医院,郑州大学附属胸科医院药学部,郑州450000 [3]广东省江门市五邑中医院药学部,江门529000 [4]济宁医学院附属医院药学部,济宁272007 [5]南昌大学第一附属医院药学部,南昌330006

出　　处：《医药导报》2023年第6期892-897,共6页Herald of Medicine

基　　金：国家自然科学基金面上项目(81873042);上海市卫计委重要薄弱学科建设项目(2016ZB302-01)。

摘　　要：5-羟色胺(5-HT)和去甲肾上腺素(NE)再摄取抑制剂(SNRIs)类药物主要在疼痛传导下行抑制通路中发挥抑制疼痛作用。SNRIs类药物广泛应用于糖尿病周围神经病理性疼痛、化疗诱导的周围神经病理性痛、幻肢痛等方面,目前为神经病理性疼痛一线推荐药物。该文就SNRIs类药物对神经病理性疼痛的作用机制及SNRIs药物在神经病理性疼痛的具体临床应用及注意事项进行综述,旨在为SNRIs类药物在神经病理性疼痛方面的临床应用提供参考。Serotonin(5-HT)and norepinephrine(NE)reuptake inhibitors(SNRIs)primarily inhibit pain by acting in descending inhibitory pathway of pain conduction.SNRIs are widely used in diabetic peripheral neuropathic pain,chemotherapy-induced peripheral neuropathic pain,phantom limb pain,etc.And SNRIs are currently recommended as the first line neuropathic pain drugs.This article summarizes the mechanical action of SNRIs on neuropathic pain,and the clinical applications and precautions of SNRIs in neuropathic pain.This article aimed to provide a reference for the clinical applications of SNRIs in neuropathic pain.

关 键 词：度洛西汀 文拉法辛 5-羟色胺和去甲肾上腺素再摄取抑制剂 神经病理性疼痛 

分 类 号：R971.43[医药卫生—药品] R745[医药卫生—药学]